Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 19;25(24):13578.
doi: 10.3390/ijms252413578.

The Diagnostic Value of Cerebrospinal Fluid Neurogranin in Neurodegenerative Diseases

Daria Krawczuk  1 , Piotr Mroczko  2 , Izabela Winkel  3 , Barbara Mroczko  1   4
Affiliations
Review

The Diagnostic Value of Cerebrospinal Fluid Neurogranin in Neurodegenerative Diseases

Daria Krawczuk et al. Int J Mol Sci. .

Abstract

Synaptic pathology is crucial in neurodegenerative diseases (NDs), and numerous studies show a correlation between synaptic proteins and the rate of cognitive decline in Alzheimer's disease, Parkinson's disease, dementia, and Creutzfeldt-Jacob's disease. Due to the fact that altered synaptic function is considered a core feature of the pathophysiology of neurodegenerative disorders, synaptic proteins, such as neurogranin, may serve as a biomarker of these diseases. Neurogranin is a postsynaptic protein located in the cell bodies and dendrites of neurons, foremost in the cerebral cortex, hippocampus, and striatum. It has been established that neurogranin is involved in synaptic plasticity and long-term potentiation. Literature data indicate that cerebrospinal fluid neurogranin may be useful as a biomarker for more accurate diagnosis and prognosis of neurodegenerative diseases. In this review, the diagnostic value of cerebrospinal fluid neurogranin in most common neurodegenerative diseases is examined.

Keywords: Alzheimer’s disease; Creutzfeldt–Jacob’s disease; Parkinson’s disease; biomarkers; neurodegeneration; neurogranin.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Localization of neurogranin.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Li H.Y., Li J.F., Lu G.W. Neurogranin: A brain-specific protein. Sheng Li Ke Xue Jin Zhan. 2003;34:111–115. (In Chinese) - PubMed
    1. Díez-Guerra F.J. Neurogranin, a link between calcium/calmodulin and protein kinase C signaling in synaptic plasticity. IUBMB Life. 2010;62:597–606. doi: 10.1002/iub.357. - DOI - PubMed
    1. Huang K.P., Huang F.L., Chen H.C. Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain. Arch. Biochem. Biophys. 1993;305:570–580. doi: 10.1006/abbi.1993.1463. - DOI - PubMed
    1. Zhong L., Cherry T., Bies C.E., Florence M.A., Gerges N.Z. Neurogranin enhances synaptic strength through its interaction with calmodulin. EMBO J. 2009;28:3027–3039. doi: 10.1038/emboj.2009.236. - DOI - PMC - PubMed
    1. Garrido-García A., de Andrés R., Jiménez-Pompa A., Soriano P., Sanz-Fuentes D., Martínez-Blanco E., Díez-Guerra F.J. Neurogranin Expression Is Regulated by Synaptic Activity and Promotes Synaptogenesis in Cultured Hippocampal Neurons. Mol. Neurobiol. 2019;56:7321–7337. doi: 10.1007/s12035-019-1593-3. - DOI - PubMed

MeSH terms

LinkOut - more resources