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Review
. 2024 Dec 21;29(24):6036.
doi: 10.3390/molecules29246036.

Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives

Teresa Glomb  1 , Julia Minta  2 , Michalina Nowosadko  2 , Julia Radzikowska  2 , Piotr Świątek  1
Affiliations
Review

Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives

Teresa Glomb et al. Molecules. .

Abstract

Compounds containing the 1,2,4-triazole moiety in their structure exhibit broad biological activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through various mechanisms, such as inhibiting COX-1/COX-2 and LOX, modulating pro-inflammatory cytokine levels, or having effects on other specific enzymes. Some also display activities in vivo. In many publications, the activities of new 1,2,4-triazole-based compounds exceed those of the reference drugs, suggesting their promising potential as new therapeutic agents. This review of active 1,2,4-triazole derivatives with anti-inflammatory activity is based on literature published from 2015-2024.

Keywords: 1,2,4-triazole; activity in vitro; activity in vivo; anti-inflammatory activity; cyclooxygenase inhibitors; lipoxygenase inhibitors.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Examples of known drugs containing a 1,2,4-triazole ring.
Figure 2
Figure 2
1,2,4-triazole derivatives as COX inhibitors (part 1).
Figure 3
Figure 3
1,2,4-triazole derivatives as COX inhibitors (part 2).
Figure 4
Figure 4
1,2,4-triazole derivatives as COX inhibitors (part 3).
Figure 5
Figure 5
1,2,4-triazole derivatives as COX inhibitors with sulfamoylphenyl or methylsulfonylphenyl substituents.
Figure 6
Figure 6
1,2,4-triazole derivatives as 15-LOX inhibitors (part 1).
Figure 7
Figure 7
1,2,4-triazole derivatives as 15-LOX inhibitors (part 2).
Figure 8
Figure 8
1,2,4-triazole derivatives as FLAP inhibitors.
Figure 9
Figure 9
1,2,4-triazole derivatives as COX-2/5-LOX inhibitors (part 1).
Figure 10
Figure 10
1,2,4-triazole derivatives as COX-2/5-LOX inhibitors (part 2).
Figure 11
Figure 11
1,2,4-triazole derivatives with confirmed anti-inflammatory activity in vivo (part 1).
Figure 12
Figure 12
1,2,4-triazole derivatives with confirmed anti-inflammatory activity in vivo (part 2).
Figure 13
Figure 13
1,2,4-triazole derivatives with confirmed anti-inflammatory activity in vivo (part 3).
Figure 14
Figure 14
1,2,4-triazole derivatives with miscellaneous mechanisms for anti-inflammatory activity (part 1).
Figure 15
Figure 15
1,2,4-triazole derivatives with miscellaneous mechanisms for anti-inflammatory activity (part 2).
See this image and copyright information in PMC

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