Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Nov 22;12(12):2391.
doi: 10.3390/microorganisms12122391.

Insights on the Pooled Prevalence and Global Distribution of Leptospirosis in Goats: Systematic Review and Meta-Analysis

Roseane de Araújo Portela  1 , Clécio Henrique Limeira  1 , José Artur Brilhante Bezerra  1 , Camila Marinelli Martins  2 , Diego Figueiredo da Costa  3 , Carolina de Sousa Américo Batista Santos  1 , Clebert José Alves  1 , Sérgio Santos de Azevedo  1
Affiliations
Review

Insights on the Pooled Prevalence and Global Distribution of Leptospirosis in Goats: Systematic Review and Meta-Analysis

Roseane de Araújo Portela et al. Microorganisms. .

Abstract

Leptospira spp. infection in small ruminants is usually asymptomatic or presents nonspecific clinical signs and has an economic impact on goat farming and public health. The aim of this study was to carry out a systematic review with meta-analysis on the global seroprevalence and distribution of leptospirosis in goats. The methodology was based on the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and the review project was registered in the International Prospective Register of Systematic Reviews (PROSPERO-ID: CRD42023405693). Overall, 79 articles were included in the study. The global prevalence of leptospirosis in goats was 18.6% (CI 95% = 15.08-22.71%), with no publication bias and high heterogeneity. The records originated from South America (n = 32), Asia (n = 26), Europe (n = 8), North America (n = 7), and Africa (n = 6), and seropositivities were 17%, 19%, 12%, 34%, and 22%, respectively. It is concluded that Leptospira spp. infection is widespread in goat herds, including regions with semi-arid and arid climates, and it is suggested that the prospects for controlling the disease should focus on avoiding environmental contamination and improving management measures and sanitary practices. This important information provides guidance for actions to protect against human contamination and to control animal leptospirosis.

Keywords: Leptospira spp.; MAT; diagnosis; serogroup; serovar; small ruminants.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the selection process for each phase and total records included in the systematic review on the global prevalence of leptospirosis in goats.
Figure 2
Figure 2
World map with the number of articles proportional to the circumference of the pie and frequency of prevalent serogroups (slices of the pie) from the articles included in the systematic review on the global prevalence of leptospirosis in goats.
Figure 3
Figure 3
Forest plot with meta-analysis by continent subgroup included in the systematic review on the global prevalence of leptospirosis in goats.
Figure 4
Figure 4
Funnel plot with the seroprevalences of the individual articles (dots) included in the systematic review on the global prevalence of leptospirosis in goats.
Figure 5
Figure 5
Summary plot of the risk of bias assessment of the 79 studies included in the systematic review on the global prevalence of leptospirosis in goats.
Figure 6
Figure 6
Word cloud of risk factors for leptospirosis in goats included in the systematic review on the global prevalence of leptospirosis in goats.
See this image and copyright information in PMC

References

    1. Karpagam K.B., Ganesh B. Leptospirose: A Neglected Tropical Zoonotic Infection of Public Health Importance—An Updated Review. Eur. J. Clin. Microbiol. Infect. Dis. 2020;39:835–846. doi: 10.1007/s10096-019-03797-4. - DOI - PubMed
    1. Haji Hajikolaei M.R., Rezaei S., Ghadrdan Mashhadi A.R., Ghorbanpoor M. The Role of Small Ruminants in the Epidemiology of Leptospirosis. Sci. Rep. 2022;12:2148. doi: 10.1038/s41598-022-05767-x. - DOI - PMC - PubMed
    1. Aymée L., Di Azevedo M.I.N., Melo J.D.S.L., Balaro M.F.A., Martins G.M.S., Consalter A., Leite J.D.S., Carvalho C.F.A., Lilenbaum W. Leptospira noguchii associated to reproductive disease in ruminants. Transbound. Emerg. Dis. 2022;69:3103–3108. doi: 10.1111/tbed.14377. - DOI - PubMed
    1. Ali S., Zhao Z., Zhen G., Kang J.Z., Yi P.Z. Reproductive Problems in Small Ruminants (Sheep and Goats): A Substantial Economic Loss in the World. [(accessed on 20 September 2022)];Large Anim. Rev. 2019 25:215–223. Available online: https://www.largeanimalreview.com/index.php/lar/issue/view/6.
    1. Martins G., Penna B., Hamond C., Leite R.C.K., Silva A., Ferreira A., Brandão F., Oliveira F., Lilenbaum W. Leptospirosis as the Most Frequent Infectious Disease Impairing Productivity in Small Ruminants in Rio de Janeiro, Brazil. Trop. Anim. Health Prod. 2012;44:773–777. doi: 10.1007/s11250-011-9964-4. - DOI - PubMed

LinkOut - more resources