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Randomized Controlled Trial
. 2024 Dec 15;16(24):4328.
doi: 10.3390/nu16244328.

The Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial

Saeede Saadati  1 , Paul Jansons  2   3 , David Scott  2   3 , Maximilian de Courten  4 , Aya Mousa  1 , Jack Feehan  5 , Jakub Mesinovic  2   3 , Barbora de Courten  2   5
Affiliations
Randomized Controlled Trial

The Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial

Saeede Saadati et al. Nutrients. .

Abstract

Background/objectives: Type 2 diabetes (T2D) is associated with an increased risk of adverse musculoskeletal outcomes likely due to heightened chronic inflammation, oxidative stress, and advanced glycation end-products (AGE). Carnosine has been shown to have anti-inflammatory, anti-oxidative, and anti-AGE properties. However, no clinical trials have examined the impact of carnosine on musculoskeletal health in adults with prediabetes or T2D.

Methods: In a randomized, double-blind clinical trial, 49 participants with prediabetes or T2D and without existing musculoskeletal conditions were assigned to receive either 2 g/day carnosine or matching placebo for 14 weeks. Whole-body dual-energy X-ray absorptiometry (DXA) was used to assess body composition, and peripheral quantitative computed tomography (pQCT) was used to assess bone health at the distal and proximal tibia.

Results: Forty-three participants completed this study. Carnosine supplementation had no effect on change in hand grip strength (HGS) or upper-limb relative strength (HGS/lean mass) versus placebo. Change in appendicular lean mass, percentage of body fat, visceral fat area, proximal tibial cortical volumetric bone mineral density (vBMD), distal tibial trabecular vBMD, and stress-strain index did not differ with carnosine compared to placebo. Fourteen weeks of carnosine supplementation did not improve muscle strength, body composition, or bone health in adults with prediabetes or T2D.

Conclusions: Carnosine supplementation may not be an effective approach for improving musculoskeletal health in adults with prediabetes and T2D without musculoskeletal conditions. However, appropriately powered trials with longer duration are warranted to confirm our findings. The trial was registered at clinicaltrials.gov (NCT02917928).

Keywords: RCT; body composition; bone health; carnosine; insulin resistance; musculoskeletal health; physical function; prediabetes; randomized trial; type 2 diabetes.

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Conflict of interest statement

The authors report no conflicts of interest. Flamma Group provided the carnosine for the intervention but then had no input on the design, conduct, analysis, or reporting of this study.

Figures

Figure 1
Figure 1
Study design and flow of participants.
See this image and copyright information in PMC

References

    1. Ong K.L., Stafford L.K., McLaughlin S.A., Boyko E.J., Vollset S.E., Smith A.E., Dalton B.E., Duprey J., Cruz J.A., Hagins H., et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402:203–234. doi: 10.1016/S0140-6736(23)01301-6. - DOI - PMC - PubMed
    1. Sarodnik C., Bours S., Schaper N., Van den Bergh J., Van Geel T. The risks of sarcopenia, falls and fractures in patients with type 2 diabetes mellitus. Maturitas. 2018;109:70–77. doi: 10.1016/j.maturitas.2017.12.011. - DOI - PubMed
    1. Hayón-Ponce M., García Fontana B., Avilés-Pérez M., González-Salvatierrra S., Moratalla Aranda E., Muñoz Torres M.E. Muscle strength as a predictor of bone fragility in patients with type 2 diabetes mellitus. Rev. Osteoporos. Metab. Miner. 2021;13:137–144. doi: 10.4321/S1889-836X2021000400006. - DOI
    1. Mesinovic J., Scott D., Seibel M.J., Cumming R.G., Naganathan V., Blyth F.M., Le Couteur D.G., Waite L.M., Handelsman D.J., Hirani V. Risk factors for incident falls and fractures in older men with and without type 2 diabetes mellitus: The Concord Health and Ageing in Men Project. J. Gerontol. Ser. A. 2021;76:1090–1100. doi: 10.1093/gerona/glab062. - DOI - PubMed
    1. Chen R., Armamento-Villareal R. Obesity and Skeletal Fragility. J. Clin. Endocrinol. Metab. 2024;109:e466–e477. doi: 10.1210/clinem/dgad415. - DOI - PMC - PubMed

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