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Review
. 2024 Nov 26;12(12):1319.
doi: 10.3390/vaccines12121319.

Recombinant Live-Attenuated Salmonella Vaccine for Veterinary Use

Domitila Brzoskowski Chagas  1 , Francisco Denis Souza Santos  1   2 , Natasha Rodrigues de Oliveira  1 , Thaís Larré Oliveira Bohn  1 , Odir Antônio Dellagostin  1
Affiliations
Review

Recombinant Live-Attenuated Salmonella Vaccine for Veterinary Use

Domitila Brzoskowski Chagas et al. Vaccines (Basel). .

Abstract

Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated Salmonella vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stability of plasmid vectors encoding protective antigens post-immunization. These vaccines are particularly suitable for production animals, providing long-term immunity against a range of bacterial, viral, and parasitic pathogens. This review summarizes the progress made in this field, with a focus on clinical trials demonstrating the efficacy and commercial potential of RASVs in veterinary medicine.

Keywords: RASV; Salmonella; animal; attenuation; vaccine development.

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Conflict of interest statement

The authors declare no conflicts of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Figures

Figure 1
Figure 1
Recombinant live-attenuated Salmonella vaccines (RASV): main characteristics and applications as veterinary vaccines for bacterial, viral, and parasitic antigens. AIV, avian influenza viruses; LPAI, low pathogenic avian influenza; TGEV, transmissible gastroenteritis virus; ASFV, African swine fever virus; DEV, duck enteritis virus; IBV, infectious bronchitis virus; PCV2, porcine circovirus type 2.
See this image and copyright information in PMC

References

    1. Roth J., Sandbulte M. The Role of Veterinary Vaccines in Livestock Production, Animal Health, and Public Health. In: Metwally S., Idrissi A.E., Viljoen G., editors. Veterinary Vaccines: Principles and Applications. Wiley; Hudson County, NJ, USA: 2021. pp. 1–10.
    1. Shaji S., Selvaraj R.K., Shanmugasundaram R. Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies. Microorganisms. 2023;11:2814. doi: 10.3390/microorganisms11112814. - DOI - PMC - PubMed
    1. Kuria J.K.N. Salmonella—Perspectives for Low-Cost Prevention, Control and Treatment. IntechOpen; London, UK: 2023. Salmonellosis in Food and Companion Animals and Its Public Health Importance.
    1. Zanella J.R.C. Zoonoses Emergentes e Reemergentes e Sua Importância Para Saúde e Produção Animal. Pesqui. Agropecuária Bras. 2016;51:510–519. doi: 10.1590/S0100-204X2016000500011. - DOI
    1. Roth J.A. Veterinary Vaccines and Their Importance to Animal Health and Public Health. Procedia Vaccinol. 2011;5:127–136. doi: 10.1016/j.provac.2011.10.009. - DOI - PMC - PubMed

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