Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Jan 7;29(1):12.
doi: 10.1186/s13054-024-05218-1.

Response to: "Inhalation NO in the HFNC group may result in a meaningless extension of survival time"

Shahin Isha  1 , Pablo Moreno Franco  1 , Devang K Sanghavi  2
Affiliations
Comment

Response to: "Inhalation NO in the HFNC group may result in a meaningless extension of survival time"

Shahin Isha et al. Crit Care. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was performed under the exemption criteria from the Mayo Clinic Institutional Review Board. Access to the multicenter Mayo Clinic data was granted through “Viral Infection and Respiratory Illness Universal Study [VIRUS]: COVID-19 Registry and Validation of C2D2 (Critical Care Data Dictionary)” under IRB ID 20–002610. The need for informed consent was waived by the IRB due to its retrospective design, data anonymity, and non-interventional nature. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Weighted Kaplan–Meier survival curve demonstrating 90-day survival from the time since iNO initiation or HFNC initiation (for the non-iNO group)
See this image and copyright information in PMC

Comment on

References

    1. Zhong L, Huang L. Inhalation NO in the HFNC group may result in a meaningless extension of survival time. Crit Care Lond Engl. 2024;28(1):370. - DOI - PMC - PubMed
    1. Isha S, Balasubramanian P, Hanson AJ, Jonna S, Raavi L, Khadka S, et al. Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study. Crit Care. 2024;28(1):344. - DOI - PMC - PubMed
    1. Austin PC. The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. Stat Med. 2014;33(7):1242–58. - DOI - PMC - PubMed
    1. Buchanan AL, Hudgens MG, Cole SR, Lau B, Adimora AA. The women’s interagency HIV study worth the weight: using inverse probability weighted cox models in AIDS research. AIDS Res Hum Retrov. 2014;30(12):1170–7. - DOI - PMC - PubMed
    1. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363(12):1107–16. - DOI - PubMed

LinkOut - more resources