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Review
. 2025 Mar 1;20(2):159-164.
doi: 10.1097/COH.0000000000000906. Epub 2024 Dec 16.

The rectal microbiome: understanding its role in HIV transmission

Francesc Català-Moll  1   2 , Roger Paredes  1   2   3   4   5   6   7   8   9
Affiliations
Review

The rectal microbiome: understanding its role in HIV transmission

Francesc Català-Moll et al. Curr Opin HIV AIDS. .

Abstract

Purpose of review: Condomless receptive anal intercourse stands out as the sexual practice with highest risk of HIV-1 infection. Recent studies have suggested that the gut microbiome influences susceptibility to HIV transmission. This review explores recent research on host risk factors, the rectal microbiome composition, local inflammation, and bacteria-derived mediators that may affect HIV transmission.

Recent findings: Constitutive host factors such as rectal mucosal structure and immune cell populations in the rectum contribute to increased susceptibility. Changes in the composition of the rectal microbiota, influenced by sexual practices and HIV infection modulate immune activation and inflammation, impacting HIV susceptibility. Bacteria-derived mediators may further influence immune responses and HIV replication in the rectal mucosa.

Summary: Understanding the role of the rectal microbiome in HIV transmission has important clinical implications. Targeted interventions that modulate the microbiome may reduce susceptibility to HIV transmission by regulating immune responses and inflammation. Further research into the host-microbiome interactions could lead to novel preventive and therapeutic strategies to mitigate HIV transmission.

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