Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan 7;112(4):854-855.
doi: 10.4269/ajtmh.24-0557. Print 2025 Apr 2.

Patch Test-Positive Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Due to Cycloserine in Multidrug-Resistant Tuberculosis: A Case Report with a Review of the Literature

Priyadharshini Basavarajpura Vijay  1 , Mrinal Kanti Das  1 , Amar Bahadur  1 , Chirantan Shivaji  1 , Tanvi Dev  1
Affiliations
Review

Patch Test-Positive Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Due to Cycloserine in Multidrug-Resistant Tuberculosis: A Case Report with a Review of the Literature

Priyadharshini Basavarajpura Vijay et al. Am J Trop Med Hyg. .

Abstract

Antitubercular treatment (ATT) is associated with multiple cutaneous adverse drug reactions. Second-line ATT is also associated with numerous adverse reactions; however, cutaneous reactions are under-reported. Oral drug provocation (ODP) in multidrug-resistant tuberculosis is challenging because of the paucity of time and the risk of developing secondary drug resistance in the case of interrupted medication. In this paper, we report a case of drug reaction with eosinophilia and systemic symptoms caused by cycloserine in an 18-year-old girl, which was confirmed with ODP and a patch test.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Central Tuberculosis Division, National Tuberculosis Elimination Programme, 2021. Guidelines for Programmatic Management of Drug Resistant Tuberculosis in India. Available at: https://tbcindia.mohfw.gov.in/wp-content/uploads/2023/05/8368587497Guide.... Accessed October 13, 2024.
    1. Calnan CH, Fregert S, Magnusson B, 1976. The International Contact Dermatitis Research Group. Cutis 18: 708–710. - PubMed
    1. Agrebi S, Saad SB, Habouria C, Daghfous H, Tritar F, 2017. Tolerance and side effects of second line anti tubercular drugs. Eur Respi J 50: PA2705.
    1. Kulthanan K, Chularojanamontri L, Manapajon A, Dhana N, Jongjarearnprasert K, 2011. Cutaneous adverse reactions to fluoroquinolones. Dermatitis 22: 155–160. - PubMed
    1. Kim H, Bang ES, Lim SK, Lee JM, 2016. DRESS syndrome and acute generalized exanthematous pustulosis induced by antituberculosis medications and moxifloxacin: Case report. Int J Clin Pharmacol Ther 54: 808–815. - PubMed

MeSH terms

LinkOut - more resources