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. 2025 Jan 1;53(1):e221-e222.
doi: 10.1097/CCM.0000000000006480. Epub 2025 Jan 7.

The authors reply

Tomoyoshi Tamura  1   2 , Hiromichi Narumiya  3 , Koichiro Homma  1   2 , Masaru Suzuki  2   4 ; Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care (HYBRID) II Study Group
Collaborators, Affiliations

The authors reply

Tomoyoshi Tamura et al. Crit Care Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Tamura’s institution received funding from Taiyo Nippon Sanso Corporation and Sanwa Kagaku Kenkyusho. Drs. Tamura and Suzuki disclosed off-label use of hydrogen gas. Dr. Homma received support for article research from corporate sponsors. Dr. Suzuki received support for article research from Taiyo Nippon Sanso Corp. Dr. Narumiya has disclosed that he does not have any potential conflicts of interest.

References

    1. Chen X, Zhang Z: Enhancing neuroprotection after cardiac arrest: The potential of hydrogen inhalation and therapeutic hypothermia. Crit Care Med 2025; 53:e219–e220
    1. Tamura T, Narumiya H, Homma K, et al.; Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care (HYBRID II) Study Group: Combination of hydrogen inhalation and hypothermic temperature control after out-of-hospital cardiac arrest: A post hoc analysis of the efficacy of inhaled hydrogen on neurologic outcome following brain ischemia during postcardiac arrest care II trial. Crit Care Med 2024; 52:1567–1576
    1. Tamura T, Suzuki M, Homma K, et al.; HYBRID II Study Group: Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): A multi-centre, randomised, double-blind, placebo-controlled trial. EClinicalMedicine 2023; 58:101907
    1. Gao Q, Song H, Wang X-T, et al.: Molecular hydrogen increases resilience to stress in mice. Sci Rep 2017; 7:9625
    1. Rahman MH, Bajgai J, Sharma S, et al.: Effects of hydrogen gas inhalation on community-dwelling adults of various ages: A single-arm, open-label, prospective clinical trial. Antioxidants (Basel) 2023; 12:1241

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