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. 2025 Jan 1;53(1):e229-e230.
doi: 10.1097/CCM.0000000000006484. Epub 2025 Jan 7.

The authors reply

Tomoyoshi Tamura  1   2 , Hiromichi Narumiya  3 , Koichiro Homma  1   2 , Motoaki Sano  2   4 , Masaru Suzuki  2   5 ; Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II Study Group
Collaborators, Affiliations

The authors reply

Tomoyoshi Tamura et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

Dr. Tamura’s institution received funding from Taiyo Nippon Sanso Corporation and Sanwa Kagaku Kenkyusho. Drs. Tamura and Suzuki disclosed off-label use of hydrogen gas. Dr. Homma received support for article research from corporate sponsors. Dr. Suzuki received support for article research from Taiyo Nippon Sanso Corp. Dr. Narumiya has disclosed that he does not have any potential conflicts of interest.

References

    1. He Y, Shan D, Xu L: Hydrogen therapy and hypothermia in cardiac arrest recovery. Crit Care Med 2025; 53:e227-e228
    1. Tamura T, Narumiya H, Homma K, et al.; Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID II) Study Group: Combination of hydrogen inhalation and hypothermic temperature control after out-of-hospital cardiac arrest: A post hoc analysis of the efficacy of inhaled hydrogen on neurologic outcome following brain ischemia during postcardiac arrest care II trial. Crit Care Med 2024; 52:1567–1576
    1. Haywood K, Whitehead L, Nadkarni VM, et al.; COSCA Collaborators: COSCA (Core Outcome Set for Cardiac Arrest) in adults: An advisory statement from the international liaison committee on resuscitation. Circulation 2018; 137:e783–e801
    1. Jin Z, Zhao P, Gong W, et al.: Fe-porphyrin: A redox-related biosensor of hydrogen molecule. Nano Res 2023; 16:2020–2025
    1. Iuchi K, Nishimaki K, Kamimura N, et al.: Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction. Can J Physiol Pharmacol 2019; 97:999–1005

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