Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr;97(5):1446-1448.
doi: 10.1038/s41390-024-03772-6. Epub 2025 Jan 7.

Biomarkers in biliary atresia - an elusive promise of predicting outcome

Barath Jagadisan  1 , Anil Dhawan  2
Affiliations

Biomarkers in biliary atresia - an elusive promise of predicting outcome

Barath Jagadisan et al. Pediatr Res. 2025 Apr.

Abstract

Research on biomarkers in BA promises to predict and change outcomes in BA. This goal is still unrealized at the moment. The study by Kamp et al attempts to understand the drivers of fibrosis and elucidate the role of amyloid-related genes in the pathophysiology of BA. Based on this, they attempt to predict outcomes in BA using biomarkers by analysing plasma samples for amyloid precursor protein. There is a need to evaluate if shifting the focus from pre-KPE biomarkers to post-KPE biomarkers, serial evaluations and the use of composite scores could help in better prognostication.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests.

References

    1. Annual report on liver transplantation - Report for 2022/2023. https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/30875/nhsbt-l.... NHS Blood and transplant - NHS England.
    1. Shneider, B. L. et al. Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J. Pediatr.170, 211–7.e1-2 (2016). - PMC - PubMed
    1. Sundaram, S. S., Mack, C. L., Feldman, A. G. & Sokol, R. J. Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. Liver Transpl.23, 96–109 (2017). - PMC - PubMed
    1. Jain, V. et al. Prognostic markers at adolescence in patients requiring liver transplantation for biliary atresia in adulthood. J. Hepatol.71, 71–77 (2019). - PubMed
    1. Chardot, C. et al. Is the Kasai operation still indicated in children older than 3 months diagnosed with biliary atresia? J. Pediatr.138, 224–228 (2001). - PubMed

LinkOut - more resources