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Meta-Analysis
. 2024 Dec 30;19(12):e0312099.
doi: 10.1371/journal.pone.0312099. eCollection 2024.

Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis

Pang Qiyuan  1 , Lin Changyang  2 , Li Gaigai  2 , Qiu Ju  2 , Zhou Xun  2
Affiliations
Meta-Analysis

Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis

Pang Qiyuan et al. PLoS One. .

Abstract

Aims: To evaluate the prognostic role of procalcitonin(PCT) on all-cause mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods: Database including PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to find relevant trials. We included studies with patients hospitalized for AECOPD, which assessed procalcitonin levels and reported on the association between procalcitonin and mortality..

Results: Fourteen trials involving 2983 patients were included. We found PCT levels in patients hospitalized for AECOPD are not associated with increased risk of mortality (RR 1.03, 95%CI 0.99-1.08). However, subgroup analysis showed PCT levels are indeed associated with an increased risk of mortality in mild to moderate AECOPD(RR 1.74, 95%CI 1.11-2.73). Deceased patients had significantly higher PCT levels, compared to survivors (MD 0.61, 95%CI 0.30-0.92). In PCT positive group, there was a significant increase in all-cause mortality(OR 3.21, 95%CI 1.84-5.61).

Conclusions: Results from this meta-analysis suggest that procalcitonin levels at the time of hospital admission for mild to moderate AECOPD are positively correlated with mortality.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Diagram illustrating the process for identifying relevant trials.
Fig 2
Fig 2. The association between procalcitonin levels and mortality in patients with AECOPD.
Fig 3
Fig 3. The association between procalcitonin levels and mortality in patients with AECOPD stratified by the severity of disease.
Fig 4
Fig 4. Meta-analysis of studies compared mortality between groups according to PCT levels.
Fig 5
Fig 5. Meta-analysis of studies compared PCT levels between survivors and deaths.
See this image and copyright information in PMC

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