Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Mar 1;117(3):565-566.
doi: 10.1093/jnci/djae343.

Re: Association of immunoglobulin E levels with glioma risk and survival

Affiliations

Re: Association of immunoglobulin E levels with glioma risk and survival

Steven Lehrer et al. J Natl Cancer Inst. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Survival probability in 280 male lower-grade glioma patients under age 70 stratified by EMSY expression (log2(fpkm-uq + 1). Higher EMSY expression (red upper curve) was associated with significantly better survival (P = .012, log rank test). fpkm-uq + 1 stands for Fragments Per Kilobase of transcript per Million mapped reads—upper quartile + 1. This normalization method is used in RNA-sequence data evaluation to facilitate cross-sample comparison and differential expression analysis.

References

    1. Guerra G, Nakase T, Kachuri L, et al. Association of immunoglobulin E levels with glioma risk and survival. J Natl Cancer Inst. 2025;117:545-553. 10.1093/jnci/djae265 - DOI - PMC - PubMed
    1. Zhu Z, Lee PH, Chaffin MD, et al. A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 2018;50:857-864. - PMC - PubMed
    1. Li X, Ampleford EJ, Howard TD, et al. The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients. J Allergy Clin Immunol. 2012;129:575-578, 578.e571-579. - PMC - PubMed
    1. Goldman MJ, Craft B, Hastie M, et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 2020;38:675-678. - PMC - PubMed
    1. Cao J, Yan W, Zhan Z, Hong X, Yan H.. Epidemiology and risk stratification of low-grade gliomas in the United States, 2004-2019: a competing-risk regression model for survival analysis. Front Oncol. 2023;13:1079597. - PMC - PubMed