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Case Reports
. 2025 Jan 7;19(1):7.
doi: 10.1007/s12105-024-01746-y.

EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Juan J Sanchez-Ramirez  1 , Matthew R Hoffman  1 , John C Keech  2 , Anthony N Snow  1 , Andrew M Bellizzi  1 , Anand Rajan  3   4   5
Affiliations
Case Reports

EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Juan J Sanchez-Ramirez et al. Head Neck Pathol. .

Abstract

We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.

Keywords: BEN domain proteins; BEND2; ESWR1::BEND2 Fusion; Gene fusion; Salivary gland carcinoma.

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Conflict of interest statement

Declarations. Ethics Approval \ Patient Consent: This report does not contain any personal identifying information. The University of Iowa Human Subjects Office determined that the study did not meet the regulatory definition of human subjects’ research as it is a report on a single case and exempted review by the IRB. Conflict of Interest: The following authors have no financial disclosures: J.J.S.R, M.R.H, J.C.K, A.N.S, A.M.B, A.R.

References

    1. Abhiman S, Iyer LM, Aravind L (2008) BEN: a novel domain in chromatin factors and DNA viral proteins. Bioinformatics 24(4):458–461. 10.1093/bioinformatics/btn007 - PMC - PubMed
    1. Todorovic E, Dickson BC, Weinreb I (2020) Salivary gland Cancer in the era of routine next-generation sequencing. Head Neck Pathol 14:311–320 - PMC - PubMed
    1. Palsgrove DN, Manucha V, Park JY, Bishop JA (2023) A low-grade Sinonasal Sarcoma harboring EWSR1::BEND2: expanding the Differential diagnosis of Sinonasal Spindle Cell Neoplasms. Head Neck Pathol 17(2):571–575. 10.1007/s12105-023-01527-z - PMC - PubMed
    1. Weinreb I, Rooper L, Bishop JA, Bell D, Dogan S, Xu B et al (eds) (2024) 3/28/2024 EWSR1::BEND2 Fusion Defines a Novel Salivary Gland Adenocarcinoma with a Predilection for the Pharynx: Description of an Emerging Entity and Validation of a Specific BEND2 Antibody. United States and Canadian Academy of Pathology 113th Annual Meeting;; Baltimore: Nature; 2024
    1. Zhang YD, Sun JJ, Xi SY, Jiang ZM, Xie DR, Yang Q, Zhang XC (2024) Malignant salivary gland neoplasm of the Tongue Base with EWSR1::BEND2 Fusion: an unusual case with Literature Review. Head Neck Pathol 18(1):118. 10.1007/s12105-024-01726-2 - PMC - PubMed

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