Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr;197(4):2555-2578.
doi: 10.1007/s12010-024-05170-4. Epub 2025 Jan 7.

Therapeutic Potential of Suaeda japonica Makino Leaf Extract Against Obesity in 3T3-L1 Preadipocytes and HFD-Induced C57BL/6 J Mice

Ajithan Chandrasekaran #  1   2 , Yongsam Jeon #  1 , Seo-Young Kim  1 , Dong-Hoon Seo  2 , Heung Joo Yuk  3 , Eunjung Son  3 , Dong-Seon Kim  3 , Seung-Hyung Kim  4 , Geung-Joo Lee  5   6
Affiliations

Therapeutic Potential of Suaeda japonica Makino Leaf Extract Against Obesity in 3T3-L1 Preadipocytes and HFD-Induced C57BL/6 J Mice

Ajithan Chandrasekaran et al. Appl Biochem Biotechnol. 2025 Apr.

Abstract

The worldwide obesity prevalence is increasing, affecting around 4 million individuals annually. This research critically evaluated the anti-obesity efficacy of the Korean mudflat halophyte herb Suaeda japonica (Suaeda japonica Makino). In the obese mice model, the administration of 200 mg/kg b.w. of S. japonica extract (SJE) significantly mitigated obesity by modulating body and organ weight, food efficiency ratio, energy expenditure, multiple blood chemistry parameters, lipid accumulation, adipose tissue hypertrophy, and various gene expressions associated with lipogenesis and thermogenesis. The significant obesity control (80%) of the aforementioned concentration of SJE treatment in mice mimics the plant-derived commercial anti-obesity drug Garcinia cambogia (Garcinia gummi-gutta) (80%, 245 mg/kg) b.w. Since SJE has not been extensively studied for obesity management, this study demonstrated that it might influence physiological, biochemical, and molecular pathways to combat obesity and related metabolic illnesses.

Keywords: Adipogenesis; Anti-obesity; Biocompounds; Gene expression; HPLC; Halophyte; Lipogenesis; Thermogenesis.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics Approval: The Institutional Animal Care and Use Committee (IACU), Daejeon University, Daejeon, Korea, granted approval for all animal treatments for this study in accordance with the National Institutes of Health’s guidance for the care and use of laboratory animals (Approval No. DJUARB2016-032). Consent to Participate: Not applicable. Consent for Publication: All authors have consented for publication. Conflict of Interest: The authors declare no competing interests. Declaration of Generative AI and AI-Assisted Technologies in the Writing Process: During the preparation of this work, the author(s) used English grammar checker QuillBot in order to improve the errorless grammatical accuracy. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.

Similar articles

See all similar articles

References

    1. Ling, J., Chen, S., Zahry, N. R., & Kao, T. A. (2023). Economic burden of childhood overweight and obesity: A systematic review and meta‐analysis. Obesity Reviews, 24(2). https://doi.org/10.1111/obr.13535
    1. Guo, W., Zhang, Z., Li, L., Liang, X., Wu, Y., Wang, X., Ma, H., Cheng, J., Zhang, A., Tang, P., & Wang, C. Z. (2022). Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes. Pharmacological Research, 182, 106355. https://doi.org/10.1016/j.phrs.2022.106355 - DOI - PubMed
    1. Adair, T. (2023). Premature cardiovascular disease mortality with overweight and obesity as a risk factor: Estimating excess mortality in the United States during the COVID-19 pandemic. International Journal of Obesity, 47(4), 273–279. https://doi.org/10.1038/s41366-023-01263-y - DOI - PubMed
    1. Kopelman, P. G. (2000). Obesity as a medical problem. Nature, 404(6778), 635–643. https://doi.org/10.1038/35007508 - DOI - PubMed
    1. Mahmood, K. T., Ghafood, S., & Tanveer, S. (2011). Risk factors contributing to hirsutism. Journal of Biomedical Science and Research, 3(1), 347–352. https://www.researchgate.net/publication/332671718

LinkOut - more resources