Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 8;37(1):21.
doi: 10.1007/s40520-024-02926-0.

Global, regional, and national burden of malignant neoplasm of bone and articular cartilage in adults aged 65 years and older, 1990-2021: a systematic analysis based on the global burden of disease study 2021

Xiang Zhang #  1 , Xiao Dai #  2 , Yuelin Chen  1 , Song Wang  1 , Hao Yang  1 , Bo Qu  1 , Hong Luo  3 , Hongsheng Yang  4
Affiliations

Global, regional, and national burden of malignant neoplasm of bone and articular cartilage in adults aged 65 years and older, 1990-2021: a systematic analysis based on the global burden of disease study 2021

Xiang Zhang et al. Aging Clin Exp Res. .

Abstract

Background: This study aims to delineate the global, regional, and national burden of malignant neoplasms of bone and articular cartilage (MNBAC) among individuals aged 65 years and older from 1990 to 2021, stratified by age, sex, and sociodemographic index (SDI).

Methods: We harnessed data from the Global Burden of Disease Study 2021 to evaluate the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) associated with MNBAC among individuals aged 65 years and older across 204 countries and territories between 1990 and 2021. The socio-demographic Index (SDI) served as a metric to examine the influence of socioeconomic development on the burden of MNBAC. Furthermore, joinpoint regression analysis was employed to identify the years marked by the most significant temporal changes over the study period.

Results: In 2021, an estimated 163,561 prevalent cases of MNBAC were recorded among individuals aged ≥ 65 years, alongside 28,100 newly diagnosed cases, 27,588 deaths, and 508,202 DALYs. The age-standardized rates per 100,000 population were 21.30 for prevalence, 3.69 for incidence, 3.66 for mortality, and 65.85 for DALYs. Notably, Cuba reported the highest prevalence rate (42.42), while the Philippines exhibited the greatest DALY burden (161.78). Egypt demonstrated the highest incidence (7.44) and mortality rates (8.90). A significant inverse correlation was observed between age-standardized DALY rates and SDI across regions.

Conclusions: This analysis underscores the substantial global burden of MNBAC among older adults, accentuating the imperative for tailored public health interventions, alongside advancements in diagnostic and therapeutic approaches, particularly within resource-constrained settings.

Keywords: Disability-adjusted life-years (DALYs); Global Burden of Disease; Malignant neoplasm of bone and articular cartilage; Mortality; Sociodemographic index.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Ethics approval and consent to participate: This study does not contain personal or medical information about an identifiable living individual, and animal subjects were not involved in the study. Consent for publication: Not applicable.

Figures

Fig. 1
Fig. 1
Age-standardized rates of prevalence (A), incidence (B), mortality (C), and disability adjusted life years (DALYs) (D) for malignant neoplasms of bone and articular cartilage in people aged ≥ 65 years across 204 countries in 2021
Fig. 2
Fig. 2
Total cases and rates of prevalence (A), incidence (B), mortality (C), and disability adjusted life years (DALYs) (D) of malignant neoplasms of bone and articular cartilage in people aged ≥ 65 years across gender and age groups in 2021. Error bars indicate the 95% certainty interval for numbers
Fig. 3
Fig. 3
Trends analyses of age-standardized rates of prevalence (A), incidence (B), mortality (C), and disability adjusted life years (DALYs) (D) for malignant neoplasms of bone and articular cartilage in people aged ≥ 65 years by gender and sociodemographic index from 1990 to 2021
Fig. 4
Fig. 4
Age-standardized rate of prevalence (A), incidence (B), mortality (C), and disability adjusted life years (DALYs) (D) due to malignant neoplasms of bone and articular cartilage in people aged ≥ 65 years by GBD regions and the expected value based on the SDI from1990 to 2021
Fig. 5
Fig. 5
Future forecasts of global burden of age-standardized rates of prevalence (A), incidence (B), mortality (C), and disability adjusted life years (DALYs) (D) by 2050 of MNBAC in people aged ≥ 65 years
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fletcher C, Bridge JA, Hogendoorn PCW, Mertens F (2013) WHO classification of tumours of soft tissue and bone: WHO classification of tumours, vol. 5 World Health Organization
    1. Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70:7–30 - PubMed
    1. Beird HC, Bielack SS, Flanagan AM et al (2022) Osteosarcoma. Nature Rev Disease Primers 8:77 - PubMed
    1. Choi JH, Ro JY (2021) The 2020 WHO Classification of Tumors of Bone: An Updated Review. Adv Anat Pathol 28:119–138 - PubMed
    1. Mirabello L, Troisi RJ, Savage SA (2009) Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer: Interdisciplinary Int J Am Cancer Soc 115:1531–1543 - PMC - PubMed

LinkOut - more resources