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Review
. 2025 Aug;37(8):e14995.
doi: 10.1111/nmo.14995. Epub 2025 Jan 8.

Gut Neuropathies and Intestinal Motility Disorders

David A Wattchow  1   2   3 , Simon J H Brookes  1 , Nick J Spencer  1 , Roberto De Giorgio  4 , Marcello Costa  1 , Phil G Dinning  1   2   3
Affiliations
Review

Gut Neuropathies and Intestinal Motility Disorders

David A Wattchow et al. Neurogastroenterol Motil. 2025 Aug.

Abstract

Background: The enteric nervous system plays a key role in the coordination of gastrointestinal motility together with sympathetic, parasympathetic, and extrinsic sensory pathways. In some cases, abnormalities in neural activity in these pathways contribute to disorders of gut motility. Where this is associated with damage or death of enteric neurons, usually detected by microscopy, this is considered a gut neuropathy.

Purpose: This review summarizes recent advances in the identification of neuropathies in a range of gastrointestinal motility disorders.

Keywords: diagnotic; digestive tract; nerve; neuropathy.

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References

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    1. M. Camilleri and J. R. Malagelada, “Abnormal Intestinal Motility in Diabetics With the Gastroparesis Syndrome,” European Journal of Clinical Investigation 14, no. 6 (1984): 420–427.
    1. H. Tufvesson, V. Hamrefors, and B. Ohlsson, “Mechanisms Behind Diffuse Idiopathic Peripheral Neuropathy in Humans—A Systematic Review,” Scandinavian Journal of Gastroenterology 58, no. 6 (2023): 572–582.

MeSH terms

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