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. 1985 Jan 15;225(2):277-81.
doi: 10.1042/bj2250277.

Leucine and tryptophan metabolism in rats

M Salter, D A Bender, C I Pogson

Leucine and tryptophan metabolism in rats

M Salter et al. Biochem J. .

Abstract

The rate of tryptophan metabolism in isolated liver cells from animals fed on a high-leucine diet was greater than for cells from control animals. Leucine inhibited tryptophan metabolism and tryptophan uptake in isolated liver cells, probably by competing for membrane transport. Leucine had no effect on tryptophan 2,3-dioxygenase in vitro. 4-Methyl-2-oxovalerate increased tryptophan oxidation in incubations containing albumin, by displacing bound tryptophan and increasing the availability of the amino acid to the cell. The results suggest that, under extreme conditions, when the availability of tryptophan is low, leucine may be pellagragenic.

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References

    1. Br J Nutr. 1983 Jul;50(1):25-32 - PubMed
    1. J Nutr. 1975 Oct;105(10):1241-52 - PubMed
    1. Biochem J. 1973 Jun;134(2):425-30 - PubMed
    1. J Nutr Sci Vitaminol (Tokyo). 1982 Feb;28(1):57-66 - PubMed
    1. J Nutr. 1978 Dec;108(12):1883-8 - PubMed

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