New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases

Yan-Rui Sun¹, Qian-Kun Lv¹, Jun-Yi Liu², Fen Wang³, Chun-Feng Liu⁴

Affiliations

¹ Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China.
² Department of Neurology, Dushu Lake hospital affilicated to Soochow University, Suzhou, China.
³ Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address: wangfen_1982@126.com.
⁴ Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address: liuchunfeng@suda.edu.cn.

PMID: 39778750
DOI: 10.1016/j.nbd.2025.106791

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Review

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases

Yan-Rui Sun et al. Neurobiol Dis. 2025 Feb.

Free article

. 2025 Feb:205:106791.

doi: 10.1016/j.nbd.2025.106791. Epub 2025 Jan 6.

Authors

Yan-Rui Sun¹, Qian-Kun Lv¹, Jun-Yi Liu², Fen Wang³, Chun-Feng Liu⁴

Affiliations

¹ Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China.
² Department of Neurology, Dushu Lake hospital affilicated to Soochow University, Suzhou, China.
³ Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address: wangfen_1982@126.com.
⁴ Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address: liuchunfeng@suda.edu.cn.

PMID: 39778750
DOI: 10.1016/j.nbd.2025.106791

Abstract

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of metabolic substances within the brain, serving functions akin to those of the peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on the removal of pathological substances in ND. This article elucidates recent discoveries regarding the glymphatic system and updates relevant concepts within its model. It discusses the potential roles of the glymphatic system in ND, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple system atrophy (MSA), and proposes the glymphatic system as a novel therapeutic target for these conditions.

Keywords: Cerebrospinal fluid; Glymphatic system; Neurodegenerative diseases; Perivascular spaces.

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Conflict of interest statement

Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases

Affiliations

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical