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Comment
. 2025 Feb;24(2):88.
doi: 10.1038/d41573-025-00002-4.

Engineered T cells traverse new terrain

Katie Kingwell
Comment

Engineered T cells traverse new terrain

Katie Kingwell. Nat Rev Drug Discov. 2025 Feb.
No abstract available

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Comment on

  • Programming tissue-sensing T cells that deliver therapies to the brain.
    Simic MS, Watchmaker PB, Gupta S, Wang Y, Sagan SA, Duecker J, Shepherd C, Diebold D, Pineo-Cavanaugh P, Haegelin J, Zhu R, Ng B, Yu W, Tonai Y, Cardarelli L, Reddy NR, Sidhu SS, Troyanskaya O, Hauser SL, Wilson MR, Zamvil SS, Okada H, Lim WA. Simic MS, et al. Science. 2024 Dec 6;386(6726):eadl4237. doi: 10.1126/science.adl4237. Epub 2024 Dec 6. Science. 2024. PMID: 39636984 Free PMC article.
  • Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.
    Reddy NR, Maachi H, Xiao Y, Simic MS, Yu W, Tonai Y, Cabanillas DA, Serrano-Wu E, Pauerstein PT, Tamaki W, Allen GM, Parent AV, Hebrok M, Lim WA. Reddy NR, et al. Science. 2024 Dec 6;386(6726):eadl4793. doi: 10.1126/science.adl4793. Epub 2024 Dec 6. Science. 2024. PMID: 39636990 Free PMC article.

References

    1. Reddy, N. R. et al. Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs. Science 386, eadl4793 (2024) - PubMed - DOI
    1. Simic, M. S. et al. Programming tissue-sensing T cells that deliver therapies to the brain. Science 386, eadl4237 (2024) - PubMed - DOI

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