Circadian rhythms are set by epigenetic marks in neurons

Debosmita Sardar et al. Nature. 2025 Jan.

. 2025 Jan;637(8047):795-796.

doi: 10.1038/d41586-024-04080-z.

No abstract available

Keywords: Animal behaviour; Brain; Epigenetics; Molecular biology.

Conflict of interest statement

The authors declare no competing interests.

Drosophila free-running rhythms require intercellular communication.
Peng Y, Stoleru D, Levine JD, Hall JC, Rosbash M. Peng Y, et al. PLoS Biol. 2003 Oct;1(1):E13. doi: 10.1371/journal.pbio.0000013. Epub 2003 Sep 15. PLoS Biol. 2003. PMID: 12975658 Free PMC article.
Circadian disruption and breast cancer: an epigenetic link?
Kochan DZ, Kovalchuk O. Kochan DZ, et al. Oncotarget. 2015 Jul 10;6(19):16866-82. doi: 10.18632/oncotarget.4343. Oncotarget. 2015. PMID: 26220712 Free PMC article. Review.
Histone methylation: at the crossroad between circadian rhythms in transcription and metabolism.
González-Suárez M, Aguilar-Arnal L. González-Suárez M, et al. Front Genet. 2024 May 16;15:1343030. doi: 10.3389/fgene.2024.1343030. eCollection 2024. Front Genet. 2024. PMID: 38818037 Free PMC article. Review.
Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders.
Liu C, Chung M. Liu C, et al. Neurosci Bull. 2015 Feb;31(1):141-59. doi: 10.1007/s12264-014-1495-3. Epub 2015 Feb 6. Neurosci Bull. 2015. PMID: 25652815 Free PMC article. Review.
Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription.
Pacheco-Bernal I, Becerril-Pérez F, Aguilar-Arnal L. Pacheco-Bernal I, et al. Clin Epigenetics. 2019 May 15;11(1):79. doi: 10.1186/s13148-019-0677-2. Clin Epigenetics. 2019. PMID: 31092281 Free PMC article. Review.

1. Zheng, Q. et al. Nature 637, 974–982 (2025). - DOI
1. Farrelly, L. A. et al. Nature 567, 535–539 (2019). - PubMed - DOI
1. Lepack, A. E. et al. Science 368, 197–201 (2020). - PubMed - DOI
1. Zhao, J. et al. Sci. Adv. 7, eabf4291 (2021). - PubMed - DOI
1. Zhao, S. et al. Proc. Natl Acad. Sci. USA 118, e2016742118 (2021). - PubMed - DOI