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Observational Study
. 2025 Jan 9;20(1):48.
doi: 10.1186/s13019-024-03312-7.

Near-infrared spectroscopy combined with vascular occlusion test to predict acute kidney injury in patients undergoing cardiac surgery: a prospective observational study

Ling Peng #  1 , Yeying Zheng #  2 , Fei Guo  2 , Mengdan Su  1 , Wei Wei  3
Affiliations
Observational Study

Near-infrared spectroscopy combined with vascular occlusion test to predict acute kidney injury in patients undergoing cardiac surgery: a prospective observational study

Ling Peng et al. J Cardiothorac Surg. .

Abstract

Background: Near-infrared spectroscopy (NIRS) enables a non-invasive measurement of tissue oxygen saturation (StO2) in regions illuminated by near-infrared lights. Vascular occlusion test (VOT) serves as a model to artificially induce forearm ischemia-reperfusion. The combination of StO2 monitoring and VOT allows for dynamic evaluation of the balance between oxygen delivery and consumption in tissue, as well as the functional reserve of microcirculation. However, the implications of these measurements for patient outcomes remain inadequately understood. This study aimed to investigate the association between StO2-VOT measurements and the occurrence of postoperative acute kidney injury (AKI), in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).

Methods: Between March 2020 and March 2021, 100 adult patients who scheduled to undergo cardiac surgery with mild hypothermic CPB were enrolled to this prospective observational study. StO2 was continuously monitored at the right forearm and ipsilateral VOT procedure was performed before initiation of CPB, at the time before weaning from CPB, and at the end of surgery. Preoperative and intraoperative factors, along with StO2-VOT parameters, were evaluated for their independent association with the occurrence of AKI following cardiac surgery. StO2-VOT parameters were also compared between patients with hyperlactatemia (peak blood lactate ≥ 4 mmol/L) and those without hyperlactatemia.

Results: In our patient population (n = 87), 13.79% (12/87) patients developed AKI after surgery. Multivariable analysis revealed that CPB time and post-CPB desaturation speed (D-speed) were independently associated with AKI. Post-CPB D-speed had an area under receiver operating characteristic (ROC) curve of 0.79 (95% CI, 0.66-0.93) with a cutoff value of 0.08%·min- 1 in predicting AKI. Patients with hyperlactatemia had longer pre-CPB T1 and higher D-speed during CPB. However, ROC analysis indicated that T1 and D-speed exhibited limited predictive capacity for hyperlactatemia. Patients with AKI exhibited an increased risk of prolonged ICU stays, postoperative stroke, reoperation, and in-hospital mortality.

Conclusions: NIRS monitoring combined with VOT shows promise in predicting postoperative AKI in patients undergoing cardiac surgery with mild hypothermic CPB.

Trial registration: ChiCTR1900021436 with registered date 21/02/2019.

Keywords: Acute kidney injury; Cardiopulmonary bypass; Hyperlactatemia; Near-infrared spectroscopy; Vascular occlusion test.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was approved by Ethics Committee of West China Hospital, Sichuan University (protocol number 2018480, Chengdu, China). All procedures performed in studies involving human participants were in accordance with the Helsinki declaration. Consent for publication: Not applicable. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Overview of StO2-VOT curve and parameters StO2, tissue oxygen saturation; VOT, vascular occlusion test
Fig. 2
Fig. 2
Flow chart depicting patient selection, along with the categorization of patients with and without AKI based on the Kidney Disease: Improving Global Outcomes (KDIGO) criteria
Fig. 3
Fig. 3
Receiver operating characteristic curve for post-CPB D-speed identified as independently associated with AKI. CBP, cardiopulmonary bypass; D-speed, desaturation speed; AKI, acute kidney injury
See this image and copyright information in PMC

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