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Review
. 2025 Mar 1;50(3):e138-e145.
doi: 10.1097/RLU.0000000000005617. Epub 2025 Jan 9.

FAP-Targeted SPECT/CT and PET/CT Imaging for Breast Cancer Patients

Jeremy McGale  1 , Sakshi Khurana  1 , Harrison Howell  1 , Abanoub Nakhla  2 , Tina Roa  1 , Parth Doshi  3 , Dorsa Shirini  4 , Alice Huang  1 , Phuong Duong  1 , Philipp Backhaus  5 , Matthew Liao  1 , Harleen Kaur  1 , Amelia McNiven Fontani  6 , Isabella Hung  6 , Neeta Pandit-Taskar  7 , Uwe Haberkorn  8 , Amit Gulati  9 , Asmâa Naim  10 , Mathieu Sinigaglia  11 , Maria Bebawy  12 , Antoine Girard  13 , Romain-David Seban  14 , Laurent Dercle  1
Affiliations
Review

FAP-Targeted SPECT/CT and PET/CT Imaging for Breast Cancer Patients

Jeremy McGale et al. Clin Nucl Med. .

Abstract

Breast cancer presents a significant global health challenge, necessitating continued innovation in diagnostic and therapeutic approaches. Recent advances have led to the identification of cancer-associated fibroblasts, which are highly prevalent in breast cancers and express fibroblast activation proteins (FAPs), as critical targets. FAP-specific radiotracers, when used with PET/CT and SPECT/CT, have significant potential for improving early breast cancer detection, staging, treatment response monitoring, and therapeutic intervention. This review provides insight into FAP-targeted molecular imaging, exploring advanced techniques for protein status assessment, development of early-phase targeted therapies, and other emerging applications. The advent of FAP-targeted imaging stands to significantly enhance personalized oncologic care, leading to improved breast cancer management and overall patient outcomes.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

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