RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

doi:10.1016/j.xjon.2024.06.019

. 2024 Jul 1:22:61-64.

doi: 10.1016/j.xjon.2024.06.019. eCollection 2024 Dec.

RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

Charles A Mack¹, Michael Jessen², Andre Lamy³, Ashish K Khanna^{4

5}, Kevin Lobdell⁶, Rakesh Arora⁷, Jeannette Rodriguez⁸, Stacey Ruiz⁸, Bhupinder Singh⁹

Affiliations

¹ Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
² Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern, Dallas, Tex.
³ Department of Perioperative Medicine and Surgery, Population Health Research Institute, Hamilton, Ontario, Canada.
⁴ Perioperative Outcomes and Informatics Collaborative, Section on Critical Care Medicine, Department of Anesthesiology, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC.
⁵ Outcomes Research Consortium, Cleveland, Ohio.
⁶ Sanger Heart and Vascular Institute, Atrium Health, Charlotte, NC.
⁷ Division of Cardiac Surgery, Department of Surgery, Harrington Heart and Vascular Institute, University Hospitals-Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.
⁸ Department of Drug Development, Renibus Therapeutics, Inc, Southlake, Tex.
⁹ Medical Office, Renibus Therapeutics, Inc, Southlake, Tex.

PMID: 39780827
PMCID: PMC11704588
DOI: 10.1016/j.xjon.2024.06.019

RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

Charles A Mack et al. JTCVS Open. 2024.

. 2024 Jul 1:22:61-64.

doi: 10.1016/j.xjon.2024.06.019. eCollection 2024 Dec.

Authors

Charles A Mack¹, Michael Jessen², Andre Lamy³, Ashish K Khanna^{4

5}, Kevin Lobdell⁶, Rakesh Arora⁷, Jeannette Rodriguez⁸, Stacey Ruiz⁸, Bhupinder Singh⁹

Affiliations

¹ Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
² Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern, Dallas, Tex.
³ Department of Perioperative Medicine and Surgery, Population Health Research Institute, Hamilton, Ontario, Canada.
⁴ Perioperative Outcomes and Informatics Collaborative, Section on Critical Care Medicine, Department of Anesthesiology, Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC.
⁵ Outcomes Research Consortium, Cleveland, Ohio.
⁶ Sanger Heart and Vascular Institute, Atrium Health, Charlotte, NC.
⁷ Division of Cardiac Surgery, Department of Surgery, Harrington Heart and Vascular Institute, University Hospitals-Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.
⁸ Department of Drug Development, Renibus Therapeutics, Inc, Southlake, Tex.
⁹ Medical Office, Renibus Therapeutics, Inc, Southlake, Tex.

PMID: 39780827
PMCID: PMC11704588
DOI: 10.1016/j.xjon.2024.06.019

No abstract available

PubMed Disclaimer

Conflict of interest statement

AKK is consultant for Renibus Therapeutics and consults for Medtronic, Edwards Lifesciences, Philips Research North America, Baxter, GE Healthcare, Potrero Medical, Retia Medical, and Caretaker Medical outside of this work. Drs Rodriguez, Ruiz, and Singh are employees of Renibus Therapeutics Inc. All other authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.

Figures

None — Influence of RBT-1 versus placebo on blood product utilization in cardiac surgery patients.

**Figure 1**
The use of blood products overall, during surgery, and after surgery are shown by treatment group. The sum of patients requiring blood product usage during surgery and postsurgery does not add up to the overall patients requiring blood products because some patients received blood products both during and postsurgery. *RBT-1*, Combination of stannic protoporfin and iron sucrose.

See this image and copyright information in PMC

References

1. Schwann T.A., Vekstein A.M., Engoren M., et al. Perioperative anemia and transfusions and late mortality in coronary artery bypass patients. Ann Thorac Surg. 2023;115(3):759–769. doi: 10.1016/j.athoracsur.2022.11.012. - DOI - PubMed
1. Zimmermann E., Zhu R., Ogami T., et al. Intraoperative autologous blood donation leads to fewer transfusions in cardiac surgery. Ann Thorac Surg. 2019;108(6):1738–1744. doi: 10.1016/j.athoracsur.2019.06.091. - DOI - PubMed
1. Salenger R., Mazzeffi M.A. The 7 pillars of blood conservation in cardiac surgery. Innovations (Phila) 2021;16(6):504–509. doi: 10.1177/15569845211051683. - DOI - PubMed
1. Schwann T.A., Habib J.R., Khalifeh J.M., et al. Effects of blood transfusion on cause-specific late mortality after coronary artery bypass grafting—less is more. Ann Thorac Surg. 2016;102(2):465–473. doi: 10.1016/j.athoracsur.2016.05.023. - DOI - PubMed
1. Lamy A., Chertow G.M., Jessen M., et al. Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. EClinicalMedicine. 2024;68 doi: 10.1016/j.eclinm.2023.102364. - DOI - PMC - PubMed

LinkOut - more resources

Full Text Sources
- Elsevier Science
- PubMed Central

[1] Schwann T.A., Vekstein A.M., Engoren M., et al. Perioperative anemia and transfusions and late mortality in coronary artery bypass patients. Ann Thorac Surg. 2023;115(3):759–769. doi: 10.1016/j.athoracsur.2022.11.012. - DOI - PubMed

[2] Schwann T.A., Vekstein A.M., Engoren M., et al. Perioperative anemia and transfusions and late mortality in coronary artery bypass patients. Ann Thorac Surg. 2023;115(3):759–769. doi: 10.1016/j.athoracsur.2022.11.012. - DOI - PubMed

[3] Zimmermann E., Zhu R., Ogami T., et al. Intraoperative autologous blood donation leads to fewer transfusions in cardiac surgery. Ann Thorac Surg. 2019;108(6):1738–1744. doi: 10.1016/j.athoracsur.2019.06.091. - DOI - PubMed

[4] Zimmermann E., Zhu R., Ogami T., et al. Intraoperative autologous blood donation leads to fewer transfusions in cardiac surgery. Ann Thorac Surg. 2019;108(6):1738–1744. doi: 10.1016/j.athoracsur.2019.06.091. - DOI - PubMed

[5] Salenger R., Mazzeffi M.A. The 7 pillars of blood conservation in cardiac surgery. Innovations (Phila) 2021;16(6):504–509. doi: 10.1177/15569845211051683. - DOI - PubMed

[6] Salenger R., Mazzeffi M.A. The 7 pillars of blood conservation in cardiac surgery. Innovations (Phila) 2021;16(6):504–509. doi: 10.1177/15569845211051683. - DOI - PubMed

[7] Schwann T.A., Habib J.R., Khalifeh J.M., et al. Effects of blood transfusion on cause-specific late mortality after coronary artery bypass grafting—less is more. Ann Thorac Surg. 2016;102(2):465–473. doi: 10.1016/j.athoracsur.2016.05.023. - DOI - PubMed

[8] Schwann T.A., Habib J.R., Khalifeh J.M., et al. Effects of blood transfusion on cause-specific late mortality after coronary artery bypass grafting—less is more. Ann Thorac Surg. 2016;102(2):465–473. doi: 10.1016/j.athoracsur.2016.05.023. - DOI - PubMed

[9] Lamy A., Chertow G.M., Jessen M., et al. Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. EClinicalMedicine. 2024;68 doi: 10.1016/j.eclinm.2023.102364. - DOI - PMC - PubMed

[10] Lamy A., Chertow G.M., Jessen M., et al. Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. EClinicalMedicine. 2024;68 doi: 10.1016/j.eclinm.2023.102364. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

Affiliations

RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

References

LinkOut - more resources

Full Text Sources