Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 1:22:61-64.
doi: 10.1016/j.xjon.2024.06.019. eCollection 2024 Dec.

RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

Charles A Mack  1 , Michael Jessen  2 , Andre Lamy  3 , Ashish K Khanna  4   5 , Kevin Lobdell  6 , Rakesh Arora  7 , Jeannette Rodriguez  8 , Stacey Ruiz  8 , Bhupinder Singh  9
Affiliations

RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery

Charles A Mack et al. JTCVS Open. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

AKK is consultant for Renibus Therapeutics and consults for Medtronic, Edwards Lifesciences, Philips Research North America, Baxter, GE Healthcare, Potrero Medical, Retia Medical, and Caretaker Medical outside of this work. Drs Rodriguez, Ruiz, and Singh are employees of Renibus Therapeutics Inc. All other authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest.

Figures

None
Influence of RBT-1 versus placebo on blood product utilization in cardiac surgery patients.
Figure 1
Figure 1
The use of blood products overall, during surgery, and after surgery are shown by treatment group. The sum of patients requiring blood product usage during surgery and postsurgery does not add up to the overall patients requiring blood products because some patients received blood products both during and postsurgery. RBT-1, Combination of stannic protoporfin and iron sucrose.
None
See this image and copyright information in PMC

References

    1. Schwann T.A., Vekstein A.M., Engoren M., et al. Perioperative anemia and transfusions and late mortality in coronary artery bypass patients. Ann Thorac Surg. 2023;115(3):759–769. doi: 10.1016/j.athoracsur.2022.11.012. - DOI - PubMed
    1. Zimmermann E., Zhu R., Ogami T., et al. Intraoperative autologous blood donation leads to fewer transfusions in cardiac surgery. Ann Thorac Surg. 2019;108(6):1738–1744. doi: 10.1016/j.athoracsur.2019.06.091. - DOI - PubMed
    1. Salenger R., Mazzeffi M.A. The 7 pillars of blood conservation in cardiac surgery. Innovations (Phila) 2021;16(6):504–509. doi: 10.1177/15569845211051683. - DOI - PubMed
    1. Schwann T.A., Habib J.R., Khalifeh J.M., et al. Effects of blood transfusion on cause-specific late mortality after coronary artery bypass grafting—less is more. Ann Thorac Surg. 2016;102(2):465–473. doi: 10.1016/j.athoracsur.2016.05.023. - DOI - PubMed
    1. Lamy A., Chertow G.M., Jessen M., et al. Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. EClinicalMedicine. 2024;68 doi: 10.1016/j.eclinm.2023.102364. - DOI - PMC - PubMed

LinkOut - more resources