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. 2025 Jan 8;10(1):277.
doi: 10.1097/j.pbj.0000000000000277. eCollection 2025 Jan-Feb.

Platelet distribution width-a prognosis marker in patients with chronic heart failure

Ana Neves  1 , Rita Gouveia  1 , Sérgio Madureira  1 , Catarina Elias  1 , Pedro Ribeirinho-Soares  1 , Marta Soares-Carreira  1 , Joana Pereira  1 , Jorge Almeida  1   2 , Patrícia Lourenço  1   2
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Platelet distribution width-a prognosis marker in patients with chronic heart failure

Ana Neves et al. Porto Biomed J. .

Abstract

Background: Increased levels of platelet distribution width (PDW) can predict cardiac death and infarction recurrence in acute myocardial infarction. PDW appears to be a prognosis marker in acute heart failure (HF); however, its impact on chronic HF is still unknown. We investigated the impact of PDW on chronic HF.

Methods: We retrospectively analyzed outpatients with chronic HF with left ventricular systolic dysfunction (LVSD) from January 2012 to May 2018. Patients with no data on PDW levels or with preserved or recovered ejection fraction were excluded. The primary end point was all-cause mortality. Multivariable Cox regression analysis was used to evaluate the association between PDW and mortality. A multivariate model was built adjusting for age, sex, comorbidities, brain-type natriuretic peptide, New York Heart Association (NYHA) class, evidence-based therapy, and severity of LVSD.

Results: In our cohort of 766 patients, 65.7% were male, the mean age was 70 years, and 35.4% were in NYHA class I; 38.3% had diabetes mellitus, 51.4% had severe LVSD, and 3.9% had an inflammatory or autoimmune disease. The median (interquartile range) PDW was 13.5 (12.1-14.9) fL. During a median follow-up of 49 (30-79) months, 372 patients (48.6%) died. Patients with PDW ≥ 14.3 fL presented a multivariate-adjusted higher risk of all-cause death than those with lower values (hazard ratio: 1.32, 95% confidence interval [CI]: 1.05-1.64, P = .2).

Conclusions: Patients with PDW ≥14.3 fL (upper tercile for PDW) presented a multivariate-adjusted 32% (95% CI: 5-64%) higher risk of all-cause death than those with lower values. PDW can help clinicians stratify patients with chronic HF; it is a practical, inexpensive, and widely available parameter.

Keywords: chronic heart failure; platelet distribution width; prognosis.

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Conflict of interest statement

The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

Figures

Figure 1.
Figure 1.
PDW distribution of the study cohort.
Figure 2.
Figure 2.
Survival curves according to PDW tertiles. Patients with PDL < 12.6 and between 12.6 and 14.3 have similar survival.
Figure 3.
Figure 3.
Survival curves according to PDW values: <14.3 fL and ≥14.3 fL. Patients in the last PDW tertile presented higher long-term mortality.
See this image and copyright information in PMC

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