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Case Reports
. 2025 Jan 7;86(1):e1-e3.
doi: 10.1055/a-2496-5240. eCollection 2025 Jan.

HPV-associated Sinonasal Squamous Cell Carcinoma

Rex H Lee  1 , Annemieke van Zante  2 , Ezequiel Goldschmidt  3 , Ivan H El-Sayed  1
Affiliations
Case Reports

HPV-associated Sinonasal Squamous Cell Carcinoma

Rex H Lee et al. J Neurol Surg Rep. .

Abstract

Human papillomavirus (HPV)-associated sinonasal squamous cell carcinoma (SNSCC) (HPV+ SNSCC) is a recently recognized entity that accounts for up to one-third of SNSCC. Although at present these cancers are not routinely tested for HPV, the incidence is increasing and HPV+ SNSCC is associated with superior survival outcomes compared with HPV- SNSCC. Here, we present the case of a patient with HPV+ SNSCC treated with endoscopic resection followed by postoperative radiation and review the literature summarizing epidemiology and management of this disease, with emphasis on the importance of HPV testing in SNSCC.

Keywords: endoscopic; human papillomavirus; sinonasal; squamous cell carcinoma.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
In-office nasal endoscopy (right nasal cavity depicted) during initial evaluation was notable for a papillary tumor along the superior edge of the right inferior turbinate and indiscernible from the middle turbinate, extending into the right ethmoids and adherent to the septum. IT, inferior turbinate; S, septum.
Fig. 2
Fig. 2
Hematoxylin and eosin (H&E) tissue section from biopsy performed in the outpatient setting, demonstrating squamous cell carcinoma. The tumor is non-keratinizing with papillary architecture.
Fig. 3
Fig. 3
Preoperative CT images (upper left and lower left) and preoperative T2-weighted MRI images (upper right and lower right) showing a 3-cm mass of the right nasal cavity indiscernible from the right middle turbinate, involving the right anterior ethmoids, and extending into the right maxillary infundibulum. The mass is abutting the right inferomedial orbit but is not exhibiting clear orbital invasion.
See this image and copyright information in PMC

References

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