Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan;19(2):43-49.
doi: 10.1080/17520363.2024.2448112. Epub 2025 Jan 9.

Predictive value of neutrophil-to-lymphocyte ratio and MELD score for short-term survival of patients with HBV-DeCi

Zhong Han  1 , Liangshuai Qi  2 , Sirui Chen  2 , Jinfei Zhang  1 , Xueliang Guo  3 , Chunying Liang  4 , Weiwei Zheng  5
Affiliations

Predictive value of neutrophil-to-lymphocyte ratio and MELD score for short-term survival of patients with HBV-DeCi

Zhong Han et al. Biomark Med. 2025 Jan.

Abstract

Objective: The prognostic value of neutrophil-to-lymphocyte ratio (NLR) combined with Model for End-Stage Liver Disease (MELD) score was evaluated for hepatitis B virus-associated decompensated cirrhosis (HBV-DeCi).

Methods: The 30-day mortality of 166 hBV-DeCi patients was examined. Receiver operating characteristic curve analysis and multivariate regression analysis were used to assess the performance of NLR for prediction of poor outcomes.

Results: The 30-day mortality rate was 10.2% (17/166). NLR was significantly lower in survivors than in non-survivors, and could be used for prognosis prediction in HBV-DeCi patients. Area under the curve was higher for NLR combined with MELD score than for each factor alone. (MELD score, AUC:0.864、NLR, AUC:0.781, Combined, AUC:0.920) The Odds ratio of MELD score is lower than NLR.(MELD score:1.447&NLR:1.745).

Conclusions: The findings demonstrate that NLR combined with MELD score has a high prognostic value for HBV-DeCi patients.

Keywords: Decompensated cirrhosis; MELD score; hepatitis B virus; mortality; neutrophil-to-lymphocyte ratio.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Similar articles

See all similar articles

References

    1. Tsochatzis EA, Bosch J, Burroughs AK.. Liver cirrhosis. Lancet. 2014;383(9930):1749–1761. doi: 10.1016/s0140-6736(14)60121-5 - DOI - PubMed
    1. Zhou J, Li X, Wang M, et al. Platelet-to-monocyte ratio as a novel promising agent for the prognosis of hepatitis B virus-associated decompensated Cirrhosis. Can J Gastroenterol & Hepatol. 2023;2023:6646156. doi: 10.1155/2023/6646156 - DOI - PMC - PubMed
    1. Kosekli MA. Mean platelet volume and platelet to lymphocyte count ratio are associated with hepatitis B-related liver fibrosis. Eur J Gastroenterol & Hepatol. 2022;34(3):324–327. doi: 10.1097/meg.0000000000002219 - DOI - PubMed

    2. •• This paper indicated that increased MPV and decreased PLR are characteristics of chronic hepatitis B disease.

    1. Xiao J, Wang F, Wong NK, et al. Global liver disease burdens and research trends: analysis from a Chinese perspective. J Hepatol. 2019;71(1):212–221. doi: 10.1016/j.jhep.2019.03.004 - DOI - PubMed
    1. Ye B, Ding Q, He X, et al. High C-Reactive protein-to-lymphocyte ratio is predictive of unfavorable prognosis in HBV-Associated decompensated Cirrhosis. Lab Med. 2022;53(6):e149–e153. doi: 10.1093/labmed/lmac019 - DOI - PubMed

LinkOut - more resources