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. 2025 Jan 9:OF1-OF23.
doi: 10.1158/2159-8290.CD-24-0499. Online ahead of print.

Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal

Ángel Fernández-Sanromán #  1   2 , Annika Fendler #  3 , Benjy J Y Tan  1 , Anne-Laure Cattin  1 , Charlotte Spencer  1   4 , Rachael Thompson  5 , Lewis Au  1   6   7 , Irene Lobon  1 , Husayn Ahmed Pallikonda  1 , Alice Martin  1 , Fiona Byrne  1 , Antonia Franz  3 , Anna Mikolajczak  8 , Haseeb Rahman  1 , Zayd Tippu  1   4 , Scott T C Shepherd  1   4 , Hugang Feng  1 , Daqi Deng  1 , Andrew Rowan  9 , Lisa Pickering  10 , Andrew J S Furness  4 , Kate Young  4 , David Nicol  10   11 , Sarah Maria Rudman  12 , Tim O'Brien  13 , Kim Edmonds  4   14 , Ashish Chandra  15 , Steve Hazell  16 , Kevin Litchfield  17 , George Kassiotis  5 , James Larkin  4 , Samra Turajlic  1   4
Affiliations

Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal

Ángel Fernández-Sanromán et al. Cancer Discov. .

Abstract

Using joint genomic-transcriptomic analysis of 243 samples, we reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor T-cell receptor coevolution, potential cGAS-STING repression, and increased cell proliferation. These patterns can aid clinical management and guide novel treatment approaches.

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