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. 1985 Jan 28;325(1-2):313-6.
doi: 10.1016/0006-8993(85)90330-0.

Regulation of intracellular pH in vertebrate central neurons

M Chesler, C Nicholson

Regulation of intracellular pH in vertebrate central neurons

M Chesler et al. Brain Res. .

Abstract

The regulation of intracellular pH (pHi) was investigated in reticulospinal neurons of the lamprey using ion-selective microelectrodes. Steady-state pHi in 23 mM HCO-3-buffered Ringer was 7.44 +/- 0.03 with a membrane potential of 54 +/- 4 mV (mean +/- S.E.M., n = 6). In nominally HCO-3-free solutions, pHi recovery from acid loading was blocked by 10(-3)M amiloride. Recovery was stimulated by transition to HCO-3-containing solutions. Results suggest that pHi regulation in lamprey reticulospinal neurons is mediated by a Na+-H+ exchanger. The presence of a distinct, HCO-3-dependent pHi regulatory mechanism is postulated.

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