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. 1985 Apr 15;55(8):1711-3.
doi: 10.1002/1097-0142(19850415)55:8<1711::aid-cncr2820550816>3.0.co;2-r.

A cell kinetic study on medulloblastomas

T Hoshino, S Kobayashi, J J Townsend, C B Wilson

A cell kinetic study on medulloblastomas

T Hoshino et al. Cancer. .

Abstract

The cell kinetics of medulloblastoma were studied to define characteristic proliferation for comparison with other neuroectodermal tumors. Four patients with cerebellar medulloblastoma received 3H-thymidine intravenously 1 to 2 days before surgery. Biopsy specimens from each tumor were processed for autoradiography. The respective average labeling indices were 14.4%, 14.1%, and 11.2% in the three mid-cerebellar medulloblastomas and 8.0% in the cerebellar hemispheric medulloblastoma. The mean survival time with various treatments including radiation therapy before or after the study in these four patients was 6 years (range, 3-9 years). In contrast, patients with malignant gliomas that had a labeling index greater than 5% died within 1 year. This difference in survival was attributed to the greater sensitivity of medulloblastoma to radiation therapy.

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