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. 1985 Mar;26(2):121-7.
doi: 10.1016/0304-3835(85)90017-5.

Oncogene expression in rat hepatomas and during hepatocarcinogenesis

G J Cote, B A Lastra, J R Cook, D P Huang, J F Chiu

Oncogene expression in rat hepatomas and during hepatocarcinogenesis

G J Cote et al. Cancer Lett. 1985 Mar.

Abstract

In this study we examined oncogene expression in several Morris hepatomas. We found elevated transcripts for Ha-ras, Ki-ras, and the myc oncogenes, while the src oncogene was not increased. Northern analysis revealed transcript sizes of 1.4 kb for Ha-ras and 2.5 kb for myc. Analysis of primary tumors induced by the carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MDAB) showed increasing oncogene transcript production with increasing length of diet. The results show enhanced ras and myc expression in rat hepatocellular carcinomas and during hepatocarcinogenesis.

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