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Comment
. 2025 Jan 10;387(6730):137-138.
doi: 10.1126/science.adu7928. Epub 2025 Jan 9.

Ena-bile-ing liver cancer growth

Wolfram Goessling  1   2   3   4
Affiliations
Comment

Ena-bile-ing liver cancer growth

Wolfram Goessling. Science. .

Abstract

Bile acids differentially affect immune cell responses to liver cancer.

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  • Bile acid synthesis impedes tumor-specific T cell responses during liver cancer.
    Varanasi SK, Chen D, Liu Y, Johnson MA, Miller CM, Ganguly S, Lande K, LaPorta MA, Hoffmann FA, Mann TH, Teneche MG, Casillas E, Mangalhara KC, Mathew V, Sun M, Jensen IJ, Farsakoglu Y, Chen T, Parisi B, Deota S, Havas A, Lee J, Chung HK, Schietinger A, Panda S, Williams AE, Farber DL, Dhar D, Adams PD, Feng GS, Shadel GS, Sundrud MS, Kaech SM. Varanasi SK, et al. Science. 2025 Jan 10;387(6730):192-201. doi: 10.1126/science.adl4100. Epub 2025 Jan 9. Science. 2025. PMID: 39787217 Free PMC article.

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