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Comparative Study
. 2025 Feb:79:103856.
doi: 10.1016/j.breast.2024.103856. Epub 2024 Dec 11.

Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study

Michael J Reinhardt  1 , Björn Ohmstede  2 , Luz Angela Torres-de la Roche  3 , Rudy Leon De Wilde  4
Affiliations
Comparative Study

Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study

Michael J Reinhardt et al. Breast. 2025 Feb.

Abstract

Objective: The necessity of preoperative lymphoscintigraphy before intraoperative sentinel lymph node (SLN) identification is still unclear. The aim of the present study was to evaluate the impact of SLN imaging on intraoperative SLN detection in breast cancer patients.

Methods: Retrospective, comparative, single center study of patients with breast cancer stage pT1 and pT2 who underwent axillary staging. Group 1 included patients who underwent SLN extirpation without preoperative SLN imaging, and Group 2 included patients who underwent SLN imaging prior to surgery. Differences between groups were analyzed using T-test and chi-square test.

Results: 926 (mean age: 61.45 years) patients received subdermal injection of radiolabeled nanocolloids between tumor and axilla. SLN was identified intraoperatively in 473 of 498 patients (94.98 %) in group 1, and in 415 of 428 patients (96.96 %) in group 2 (p = 0.129). Lymphoscintigraphy detected SLN in 407 of 428 (95.09 %) patients in group 2. Due to the additional SLN imaging in group 2, the time between radiotracer injection and start of surgery was significantly prolonged (p < 0.001). A reduction of applied activity from a median of 18 MBq in group 1 to a median of 12 MBq in group 2 had no negative effect on the SLN identification.

Conclusion: Subdermal injection of radiolabeled nanocolloids between tumor and axilla allowed high intraoperative detection of SLN. Preoperative SLN imaging had no significant impact on the intraoperative detection but is a time-consuming and resource-intensive procedure. Prospective studies might provide further evidence to omit preoperative SLN imaging in patients with T1-2 invasive breast cancer and clinically negative axilla.

Keywords: Breast cancer; Scintigraphy; Sentinel lymph node.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no competing financial interests or personal relationships that could influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Lymph node detection rate in dependence on pre-operative imaging.
Fig. 2
Fig. 2
Administered net activity for SLN identification.
Fig. 3
Fig. 3
Time between radiotracer injection and start of surgery in dependence on pre-operative sentinel lymph node imaging.
See this image and copyright information in PMC

References

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