doi: 10.1016/j.chom.2024.12.011.
Linking E. coli to fibrosis in Crohn's disease
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- PMID: 39788093
- DOI: 10.1016/j.chom.2024.12.011
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Linking E. coli to fibrosis in Crohn's disease
Cell Host Microbe.
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Abstract
Intestinal fibrosis associated with Crohn's disease is a serious yet poorly understood clinical complication. In this issue of Cell Host & Microbe, Ahn and colleagues provide evidence that the adherent intestinal E. coli produced the metallophore yersiniabactin, which sequesters zinc to drive intestinal fibrosis in a HIF-1α-dependent manner.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
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