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Review
. 2024 Jul 28;49(7):1052-1061.
doi: 10.11817/j.issn.1672-7347.2024.240025.

Correlation between obesity and Alzheimer ' s disease and the mechanisms

[Article in English, Chinese]
Tenglin Zhang  1   2 , Ping Wang  3 , Ruonan Li  3   4 , Ying Wang  5 , Shuxun Yan  6
Affiliations
Review

Correlation between obesity and Alzheimer ' s disease and the mechanisms

[Article in English, Chinese]
Tenglin Zhang et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Alzheimer's disease (AD) is a progressive central neurodegenerative disorder with an insidious onset. With global aging, the incidence and mortality of AD have been steadily increasing, yet effective treatments remain elusive. Obesity, characterized by excessive or abnormal fat accumulation, is a complex metabolic disorder and a confirmed risk factor for numerous diseases. Both obesity and AD have become major public health concerns, posing significant threats to human health and economic development. Studies have revealed a strong correlation between obesity and AD, with multiple contributing factors, including metabolic abnormalities of endocrine factors, inflammatory responses, and genetic interactions. Exploring the correlation and mechanisms between obesity and AD provides important insights and new strategies for the prevention and treatment of AD.

阿尔茨海默病(Alzheimer’s disease，AD)是一种起病隐匿的进行性发展的中枢神经退行性疾病。随着人口老龄化，全球AD的发病率和病死率逐年上升，但目前仍没有非常有效的治疗方法。肥胖是一种体内脂肪堆积过多或分布异常的代谢异常性疾病，其病因复杂，已被证实是多种疾病的危险因素。现阶段，AD和肥胖均已成为威胁人类健康和影响经济发展的重大公共卫生问题。研究发现，肥胖与AD的发病密切相关，二者通过内分泌环境因子代谢异常、炎症反应和遗传基因等多种因素相互作用。探究肥胖与AD之间的相关性及作用机制，对未来AD的预防与治疗提供新的思路与方法具有重要的参考意义。.

Keywords: Alzheimer’s disease; adipokines; gene; inflammation; insulin resistance; obesity; sex hormones.

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Conflict of interest statement

作者声称无任何利益冲突。

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