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. 2025 May 1;44(5):439-441.
doi: 10.1097/INF.0000000000004684. Epub 2025 Jan 9.

Comorbidities Associated With Different Degrees of Severity in Children and Young People Hospitalized With Acute COVID-19

Irati Gastesi  1 , Sara Domínguez-Rodríguez  1   2 , Marthe Le Prevost  3 , Andrea Ramírez  4 , Carlo Giaquinto  5   6 , María Lucía Mesa  7 , Alvaro Ballesteros  1 , Charlotte Jackson  3 , Pablo Vásquez-Hoyos  8 , Carlos Alvarez Moreno  9 , Carlos Grasa  10   11 , Cristina Epalza  12 , Antoni Soriano-Arandes  13 , Cinta Moraleda  1   12 , Alfredo Tagarro  1   2   14
Affiliations

Comorbidities Associated With Different Degrees of Severity in Children and Young People Hospitalized With Acute COVID-19

Irati Gastesi et al. Pediatr Infect Dis J. .

Abstract

In this prospective cohort study with 2326 hospitalized children and young people with coronavirus disease 2019 in Spain and Colombia, 36.4% had comorbidities. Asthma, recurrent wheezing, chronic neurological, cardiac and pulmonary diseases significantly increased the risk of severe outcomes such as death, mechanical ventilation and intensive care unit admission. The incremental risk with additional comorbidities underscores the importance of targeted vaccination strategies for vulnerable children and young people populations.

Keywords: SARS-CoV-2; adolescents; comorbidities; pediatrics; respiratory infection.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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