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. 2025 Feb;24(2):91.

doi: 10.1038/d41573-025-00004-2.

DNA-PKcs inhibitor causes genomic alterations

Sarah Crunkhorn

PMID: 39794508
DOI: 10.1038/d41573-025-00004-2

Comment

DNA-PKcs inhibitor causes genomic alterations

Sarah Crunkhorn. Nat Rev Drug Discov. 2025 Feb.

. 2025 Feb;24(2):91.

doi: 10.1038/d41573-025-00004-2.

Author

Sarah Crunkhorn

PMID: 39794508
DOI: 10.1038/d41573-025-00004-2

No abstract available

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Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.
Cullot G, Aird EJ, Schlapansky MF, Yeh CD, van de Venn L, Vykhlyantseva I, Kreutzer S, Mailänder D, Lewków B, Klermund J, Montellese C, Biserni M, Aeschimann F, Vonarburg C, Gehart H, Cathomen T, Corn JE. Cullot G, et al. Nat Biotechnol. 2024 Nov 27. doi: 10.1038/s41587-024-02488-6. Online ahead of print. Nat Biotechnol. 2024. PMID: 39604565

References

1. Cullot, G. et al. Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02488-6 (2024)

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