DNA-PKcs inhibitor causes genomic alterations

Comment

Sarah Crunkhorn. Nat Rev Drug Discov. 2025 Feb.

. 2025 Feb;24(2):91.

doi: 10.1038/d41573-025-00004-2.

No abstract available

Comment on

Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.
Cullot G, Aird EJ, Schlapansky MF, Yeh CD, van de Venn L, Vykhlyantseva I, Kreutzer S, Mailänder D, Lewków B, Klermund J, Montellese C, Biserni M, Aeschimann F, Vonarburg C, Gehart H, Cathomen T, Corn JE. Cullot G, et al. Nat Biotechnol. 2025 Nov;43(11):1778-1782. doi: 10.1038/s41587-024-02488-6. Epub 2024 Nov 27. Nat Biotechnol. 2025. PMID: 39604565 Free PMC article.

1. Cullot, G. et al. Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02488-6 (2024)