Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 29;15(1):57.
doi: 10.3390/diagnostics15010057.

PostCOVID-19 Impact on Perinatal Outcomes

Gaukhar Kurmanova  1 , Ardak Ayazbekov  2 , Almagul Kurmanova  1 , Madina Rakhimbayeva  1 , Gulzhan Trimova  1 , Anarkul Kulembayeva  3
Affiliations

PostCOVID-19 Impact on Perinatal Outcomes

Gaukhar Kurmanova et al. Diagnostics (Basel). .

Abstract

Background. Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) infection during pregnancy was associated with a number of adverse pregnancy outcomes, including miscarriage, preeclampsia, preterm birth, and stillbirth. The virus persistence can last for a long time, and the consequences of a previous coronavirus infection are currently under study. Objectives. This study aimed to establish the clinical features of the course of pregnancy and childbirth in women with a history of asymptomatic coronavirus disease 2019 (COVID-19). Methods. This study was conducted in the Regional Perinatal Center N3 of Turkestan city, Kazakhstan. A total of 229 participants were enrolled comprising individuals with (n = 133, exposed group) from August to September 2021 with a history of COVID-19 and without one in the same period in 2019 (n = 96, unexposed group). Results. There is a statistically significant strong association between a history of COVID-19 and the development of oligohydramnios (φ = 0.743, p < 0.001), and medium strength between a history of COVID-19 and the presence of anemia (φ = 0.254, p < 0.001), abnormal development of the placenta (φ = 0.254, p < 0.011), cord entanglement (φ = 0.343, p = 0.000), low birth weight (φ = 0.356, p < 0.001) and stillbirth (φ = 0.293, p < 0.001). Conclusions. The past COVID-19 infection in pregnant women has long-term consequences in the form of placenta abnormal development and oligohydramnios; and, as a result, the development of adverse perinatal outcomes.

Keywords: COVID-19; oligohydramnios; placenta; pregnancy; stillbirth.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

References

    1. Zambrano L.D., Ellington S., Strid P., Galang R.R., Oduyebo T., Tong V.T., Woodworth K.R., Nahabedian J.F., Azziz-Baumgartner E., Gilboa S.M., et al. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status—United States, January 22-October 3, 2020. MMWR Morb. Mortal. Wkly. Rep. 2020;69:1641–1647. doi: 10.15585/mmwr.mm6944e3. - DOI - PMC - PubMed
    1. Metz T.D., Clifton R.G., Hughes B.L., Sandoval G., Saade G.R., Grobman W.A., Manuck T.A., Miodovnik M., Sowles A., Clark K., et al. Disease Severity and Perinatal Outcomes of Pregnant Patients with Coronavirus Disease 2019 (COVID-19) Obstet. Gynecol. 2021;137:571–580. doi: 10.1097/AOG.0000000000004339. - DOI - PMC - PubMed
    1. Kelly J.C., Raghuraman N., Carter E.B., Palanisamy A., Stout M.J. Preprocedural asymptomatic coronavirus disease 2019 cases in obstetrical and surgical units. Am. J. Obstet. Gynecol. 2021;224:114–116. doi: 10.1016/j.ajog.2020.09.023. - DOI - PMC - PubMed
    1. Tanacan A., Erol S.A., Turgay B., Anuk A.T., Secen E.I., Yegin G.F., Ozyer S., Kirca F., Dinc B., Unlu S., et al. The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020;253:31–34. doi: 10.1016/j.ejogrb.2020.07.051. - DOI - PMC - PubMed
    1. Di Mascio D., Sen C., Saccone G., Galindo A., Grünebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Rodríguez Suárez M.J., et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): A secondary analysis of the WAPM study on COVID-19. J. Perinat. Med. 2020;48:950–958. doi: 10.1515/jpm-2020-0355. - DOI - PubMed

LinkOut - more resources