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Review
. 2024 Dec 24;17(1):4.
doi: 10.3390/cancers17010004.

Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances

Meryl B Kravitz  1   2 , Vivek Annadata  3 , Benjamin Ilyaev  3 , Charles C L Tong  1 , Judd H Fastenburg  1 , Mark B Chaskes  1
Affiliations
Review

Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances

Meryl B Kravitz et al. Cancers (Basel). .

Abstract

Squamous cell carcinoma is the most common malignancy affecting the sinonasal tract. Local recurrence is the main pattern of treatment failure, affecting nearly half of patients treated for primary sinonasal squamous cell carcinoma (SNSCC). Due to disease rarity and heterogeneity of practices, there are limited guidelines for how to diagnose and care for these patients. This paper reviews current evidence regarding etiology, pathophysiology, diagnosis, prognostic factors, and treatment modalities of recurrent SNSCC (rSNSCC). Currently, salvage surgery offers the only durable approach for eligible patients. These resections often require robust reconstructive options due to prior surgery or radiation. Chemoradiation is offered as an adjuvant or palliative approach when surgery is not a feasible option. Emerging options such as immunotherapy and particle therapy remain an area of ongoing investigation.

Keywords: endoscopic; open; recurrence; sinonasal; squamous cell carcinoma; tumor.

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Conflict of interest statement

None of the authors have any disclosures.

Figures

Figure 1
Figure 1
Recurrent sinonasal squamous cell carcinoma—proposed treatment algorithm.
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