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Review
. 2024 Dec 25;17(1):21.
doi: 10.3390/cancers17010021.

Prospects for Narrow Band Imaging Magnification Endoscopy in Oral Lesions: Recommendations from Oral and Maxillofacial Surgeons and a Gastroenterologist

Toshimi Chiba  1 , Airi Ota  2 , Taifu Hirano  2 , Tadashi Kawai  2 , Atsushi Ogawa  2 , Hiroyuki Yamada  2
Affiliations
Review

Prospects for Narrow Band Imaging Magnification Endoscopy in Oral Lesions: Recommendations from Oral and Maxillofacial Surgeons and a Gastroenterologist

Toshimi Chiba et al. Cancers (Basel). .

Abstract

Narrow band imaging (NBI) magnification endoscopy for the diagnosis of early-stage oral cavity-related cancer and precancerous lesions can recognize oral lesions as brownish areas, and can observe intraepithelial papillary capillary loops (IPCLs) in the mucosa and submucosa to make a qualitative diagnosis of the lesion and highlight the mucosal surface microstructure to facilitate appropriate diagnosis and early treatment. IPCLs are classified from Type 0 to IV: Type 0 is normal mucosa or no blood vessels observed, e.g., in keratinization; Type I is mainly normal mucosa; Type II is mainly inflammatory sites or non-malignant lesions; Type III is mainly precancerous or suspected malignant lesions; and Type IV is cancerous or malignant lesions. NBI magnification endoscopy is a useful noninvasive method for identifying the malignant transformation of oral potentially malignant disorders (OPMDs). Oral lesions classified as IPCL Type II or higher are atypical epithelial or oral squamous cell carcinoma (OSCC); oral biopsy is recommended for early and accurate diagnosis, and is an indicator of the appropriate biopsy site in the follow-up for OPMDs. In the future, the accuracy of NBI magnification endoscopy for malignant transformation of OPMDs and OSCC will be further confirmed.

Keywords: intraepithelial papillary capillary loops; magnification endoscopy; narrow band imaging; oral potentially malignant disorders; oral squamous cell carcinoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Type 0 is shown in the circle: No vessels are observed due to normal mucosa or keratinisation, etc.
Figure 2
Figure 2
Type I is shown in the circle: Regular brown dots are observed when IPCLs are perpendicular to the mucosa, and waved lines are observed when running parallel. Most of the mucosa is normal.
Figure 3
Figure 3
Type II is shown in the circle: IPCLs are dilated and crossing. They are mainly at inflammatory sites or non-malignant lesions.
Figure 4
Figure 4
Type III is shown in the circle: IPCLs are further elongated and meandering. This is mainly seen in precancerous or suspected malignant lesions.
Figure 5
Figure 5
Type IV is shown in the circle: IPCLs are characterized by large vessels, destruction of looped vascular structures, and angiogenesis. This suggests the possibility of cancerous or malignant lesions.
See this image and copyright information in PMC

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