Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 27;17(1):54.
doi: 10.3390/cancers17010054.

Metabolic-Modulating Effects of Radiation: Undetectable Yet Deadly-A Review on Radiotherapy

Francesco Fiorica  1 , Umberto Tebano  1 , Giuseppe Napoli  1 , Antonella Franceschetto  1 , Marco Muraro  1 , Carlotta Giorgi  2 , Paolo Pinton  2
Affiliations
Review

Metabolic-Modulating Effects of Radiation: Undetectable Yet Deadly-A Review on Radiotherapy

Francesco Fiorica et al. Cancers (Basel). .

Abstract

From a cancer-centric perspective, radiotherapy has been primarily viewed as a localised treatment modality, targeting cancer tissues with ionising radiation to induce DNA damage and cell death [...].

Keywords: Metabolic cancer pathway and radiotherapy; alternative radiation cell killing; radiation synergism.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Radiation induces a metabolic vulnerability in cells due to the Warburg effect.
Figure 2
Figure 2
Radiation induces a metabolic vulnerability in cells, causing lipid synthesis.
Figure 3
Figure 3
Radiation induces a metabolic vulnerability in amino acid pathways.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lomax M.E., Folkes L.K., O’Neill P. Biological Consequences of Radiation-Induced DNA Damage: Relevance to Radiotherapy. Clin. Oncol. 2013;25:578–585. doi: 10.1016/j.clon.2013.06.007. - DOI - PubMed
    1. Okada H., Mak T.W. Pathways of Apoptotic and Non-Apoptotic Death in Tumour Cells. Nat. Rev. Cancer. 2004;4:592–603. doi: 10.1038/nrc1412. - DOI - PubMed
    1. Cannan W.J., Pederson D.S. Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin. J. Cell. Physiol. 2016;231:3. doi: 10.1002/jcp.25048. - DOI - PMC - PubMed
    1. Bortfeld T., Jeraj R. The Physical Basis and Future of Radiation Therapy. Br. J. Radiol. 2011;84:485. doi: 10.1259/bjr/86221320. - DOI - PMC - PubMed
    1. Otto K. Volumetric Modulated Arc Therapy: IMRT in a Single Gantry Arc. Med. Phys. 2008;35:310–317. doi: 10.1118/1.2818738. - DOI - PubMed

LinkOut - more resources