DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome
- PMID: 3980018
- DOI: 10.1007/BF00293038
DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome
Abstract
Recombinant plasmid clone B74 (also named D18 S3) containing a human single-copy DNA segment of 6 kilobases (kb) was localized by in situ hybridization on band p113 of chromosome 18. This probe was then used in cytogenetic diagnosis to identify precisely a small supernumerary chromosome as an isochromosome i(18p).