Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance

Helen Stark¹, Quan Yao Ho^{1

2}, Amy Cross¹, Alessandro Alessandrini³, Alice Bertaina⁴, Daniel Brennan⁵, Stephan Busque⁶, Anthony Demetris⁷, Luke Devey⁸, Gilbert Fruhwirth⁹, Ephraim Fuchs¹⁰, Peter Friend¹¹, Ed Geissler¹², Carole Guillonneau¹³, Joanna Hester¹, John Isaacs^{14

15}, Elmar Jaeckel¹⁶, Tatsuo Kawai¹⁷, Fadi Lakkis¹⁸, Joseph Leventhal¹⁹, Megan Levings²⁰, Josh Levitsky²¹, Giovanna Lombardi²², Marc Martinez-Llordella⁸, James Mathew²³, Aurélie Moreau²⁴, Petra Reinke²⁵, Leonardo V Riella^{3

26}, David Sachs^{27

28

29}, Alberto Sanchez Fueyo³⁰, Katharina Schreeb³¹, Megan Sykes³², Qizhi Tang³³, Angus Thomson³⁴, Timothy Tree³⁵, Piotr Trzonkowski³⁶, Koichiro Uchida³⁷, Jeffrey Veale³⁸, Josh Weiner³⁹, Thomas Wekerle⁴⁰, Fadi Issa¹

Affiliations

¹ Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
² Department of Renal Medicine, Singapore General Hospital, Singapore.
³ Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
⁴ Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
⁵ Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.
⁶ Department of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Palo Alto, CA.
⁷ Department of Pathology, Division of Transplantation, University of Pittsburgh, Pittsburgh, PA.
⁸ Quell Therapeutics, Translation and Innovation Hub, London, UK.
⁹ Imaging Therapies and Cancer Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
¹⁰ ImmunoFree Inc.
¹¹ Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
¹² Division of Experimental Surgery, Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
¹³ Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, Nantes, France.
¹⁴ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
¹⁵ Musculoskeletal Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
¹⁶ Ajmera Transplant Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.
¹⁷ Department of Surgery, Transplant Center, Massachusetts General Hospital, Boston, MA.
¹⁸ Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
¹⁹ Comprehensive Transplant Center at Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL.
²⁰ Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
²¹ Department of Medicine, Northwestern University, Chicago, IL.
²² Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London, UK.
²³ Departments of Surgery and Microbiology-Immunology, Comprehensive Transplant Center, Northwestern University, Chicago, IL.
²⁴ INSERM, Nantes Université, CHU Nantes, Center for Research in Transplantation and Translational Immunology, Nantes, France.
²⁵ Charité - Universitätsmedizin Berlin, Berlin Center for Advanced Therapies (BeCAT), Berlin, Germany.
²⁶ Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
²⁷ Department of Surgery, Massachusetts General Hospital, Harvard University, Boston, MA.
²⁸ Medical School, Harvard University, Boston, MA.
²⁹ Columbia Center of Translational Immunology, Columbia University Medical Center, New York, NY.
³⁰ Institute of Liver Studies, King's College Hospital, London, UK.
³¹ Sangamo Therapeutics, Gloucestershire, UK.
³² Columbia Center for Translational Immunology, Departments of Medicine, Surgery, and Microbiology and Immunology, Columbia University, New York, NY.
³³ Department of Surgery, Diabetes Center, University of California, San Francisco, CA.
³⁴ Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
³⁵ Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.
³⁶ Medical University of Gdansk, Department of Medical Immunology, Gdansk, Poland.
³⁷ Juntendo University Center for Immunotherapy and Diagnosis, Juntendo University Graduate School of Medicine, Tokyo, Japan.
³⁸ Department of Urology, University of California, Los Angeles, CA.
³⁹ Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY.
⁴⁰ Division of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.

PMID: 39800883
DOI: 10.1097/TP.0000000000005311

Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance

Helen Stark et al. Transplantation. 2025.

. 2025 Apr 1;109(4):569-579.

doi: 10.1097/TP.0000000000005311. Epub 2025 Jan 13.

Authors

Affiliations

¹ Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
² Department of Renal Medicine, Singapore General Hospital, Singapore.
³ Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
⁴ Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
⁵ Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.
⁶ Department of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Palo Alto, CA.
⁷ Department of Pathology, Division of Transplantation, University of Pittsburgh, Pittsburgh, PA.
⁸ Quell Therapeutics, Translation and Innovation Hub, London, UK.
⁹ Imaging Therapies and Cancer Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
¹⁰ ImmunoFree Inc.
¹¹ Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
¹² Division of Experimental Surgery, Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
¹³ Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, Nantes, France.
¹⁴ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
¹⁵ Musculoskeletal Unit and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
¹⁶ Ajmera Transplant Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.
¹⁷ Department of Surgery, Transplant Center, Massachusetts General Hospital, Boston, MA.
¹⁸ Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
¹⁹ Comprehensive Transplant Center at Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL.
²⁰ Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
²¹ Department of Medicine, Northwestern University, Chicago, IL.
²² Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, London, UK.
²³ Departments of Surgery and Microbiology-Immunology, Comprehensive Transplant Center, Northwestern University, Chicago, IL.
²⁴ INSERM, Nantes Université, CHU Nantes, Center for Research in Transplantation and Translational Immunology, Nantes, France.
²⁵ Charité - Universitätsmedizin Berlin, Berlin Center for Advanced Therapies (BeCAT), Berlin, Germany.
²⁶ Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
²⁷ Department of Surgery, Massachusetts General Hospital, Harvard University, Boston, MA.
²⁸ Medical School, Harvard University, Boston, MA.
²⁹ Columbia Center of Translational Immunology, Columbia University Medical Center, New York, NY.
³⁰ Institute of Liver Studies, King's College Hospital, London, UK.
³¹ Sangamo Therapeutics, Gloucestershire, UK.
³² Columbia Center for Translational Immunology, Departments of Medicine, Surgery, and Microbiology and Immunology, Columbia University, New York, NY.
³³ Department of Surgery, Diabetes Center, University of California, San Francisco, CA.
³⁴ Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
³⁵ Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.
³⁶ Medical University of Gdansk, Department of Medical Immunology, Gdansk, Poland.
³⁷ Juntendo University Center for Immunotherapy and Diagnosis, Juntendo University Graduate School of Medicine, Tokyo, Japan.
³⁸ Department of Urology, University of California, Los Angeles, CA.
³⁹ Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY.
⁴⁰ Division of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.

PMID: 39800883
DOI: 10.1097/TP.0000000000005311

No abstract available

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Conflict of interest statement

D.B. is a professor in the Department of Internal Medicine at the Johns Hopkins University School of Medicine. D.B. is a private consultant for Medeor Therapeutics and did not engage in research in his capacity as a Johns Hopkins faculty member. D.B. was compensated for the consulting or advising service in income from Medeor Therapeutics. E.F. is a professor in the Department of Oncology at the Johns Hopkins University School of Medicine. E.F. engaged in this research as a private consultant or advisor and not in his capacity as a Johns Hopkins faculty member. E.F. was compensated for the consulting oradvising service in income and equity in ImmunoFree Inc. L.D. is an employee of Quell Therapeutics. M.M.-L. is the founder of Quell Therapuetics and inventor of several patents on Treg therapy. P.R. is the founder of TCbalance pharmaceutical, UKRMP Programme Board Member, scientific advisor of MIGENTRA GmbH, Fraunhofer IBMT, Fabre GmbH, Novo Nordisk, and Sangamo Therapeutic France; and inventor of several patents on Treg therapy. K.S. is an employee of Sangamo Therapeutics. Q.T. is a co-founder, shareholder, and scientific advisor of Sonoma Biotherapeutics. Q.T. is a consultant of Genesis, Qihan Bio, Moderna, Minutia, and Waypoint Bio. Q.T. is an inventor of several patents on Treg therapy. P.T. is co-inventor of patents related to the presented content and stakeholder of the POLTREG venture. The Medical University of Gdansk received payment for the license to the given content. K.U. is a co-founder and shareholder of Juntenbio. The other authors declare no conflicts of interest.

References

1. Podestà MA, Binder C, Sellberg F, et al. Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro. Am J Transplant. 2020;20:88–100.
1. Sprangers B, DeWolf S, Savage TM, et al. Origin of enriched regulatory T cells in patients receiving combined kidney-bone marrow transplantation to induce transplantation tolerance. Am J Transplant. 2017;17:2020–2032.
1. Kawai T, Sachs DH, Sprangers B, et al. Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant. 2014;14:1599–1611.
1. Morris H, DeWolf S, Robins H, et al. Tracking donor-reactive T cells: evidence for clonal deletion in tolerant kidney transplant patients. Sci Transl Med. 2015;7:272ra10.
1. Savage TM, Shonts BA, Obradovic A, et al. Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight. 2018;3:e124086.

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Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance

Affiliations

Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance

Authors

Affiliations

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources