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. 2025 Jan;29(1):75-83.
doi: 10.5005/jp-journals-10071-24884. Epub 2024 Dec 30.

Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review

Moirangthem Sonia  1 , Sukhpal Kaur  2 , Nikhil Kothari  3
Affiliations

Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review

Moirangthem Sonia et al. Indian J Crit Care Med. 2025 Jan.

Abstract

Introduction: Delirium is a syndrome commonly seen in intensive care unit (ICU) patients. It is characterized by acute changes in mental status, inattention, disorganized thinking, and altered level of consciousness. Due to its higher prevalence in mechanically ventilated ICU patients, it is crucial to recognize it early and implement standardized evidence-based protocols for preventing it in regular practice.

Objectives: To identify the benefits and effectiveness of nonpharmacological interventions for preventing delirium among critically ill patients admitted to the ICU.

Methods: The preferred reporting items for systematic reviews and meta-analyses statement guidelines were followed. Two independent authors searched electronic and grey literature for systematic review and meta-analysis in the following databases: PubMed, Scopus, Web of Science, Cochrane Database of Systematic Reviews, and Google Scholar.

Results: This umbrella review included 12 studies on delirium prevention interventions, excluding reviews, abstracts, case studies, and pharmacological interventions. Our finding shows that multicomponent strategies are the most promising intervention for preventing delirium. Inclusion of family participation is the most vital part, with flexible visitation to be included in delirium care protocols. Multidisciplinary approaches raise workloads among healthcare professionals through increased coordination, assessments, and documentation.

Conclusions: Multicomponent interventions are regarded as the most effective among all nonpharmacological interventions for reducing and preventing delirium.

Highlights: Delirium syndrome is preventable among mechanically ventilated patients. The study aims to identify the benefits and effectiveness of nonpharmacological interventions for preventing delirium among critically ill patients admitted to the ICU.

How to cite this article: Sonia M, Kaur S, Kothari N. Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review. Indian J Crit Care Med 2025;29(1):75-83.

Keywords: Critical care; Delirium; Meta-analysis; Nonpharmacological interventions; Systematic review.

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Conflict of interest statement

Source of support: Nil Conflict of interest: NoneConflict of interest: None

Figures

Fig. 1
Fig. 1
Preferred reporting items for systematic reviews and meta-analyses (PRISMA) flow diagram
Fig. 2
Fig. 2
Year-wise distribution of studies
See this image and copyright information in PMC

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