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Review
. 2025 Jan 13;29(1):25.
doi: 10.1007/s11916-024-01318-3.

A Review of the Prospera Spinal Cord Stimulation System with Multiphase Stimulation and Proactive Care

Ramana K Naidu  1 , Leonardo Kapural  2 , Sean Li  3 , Caitlin Tourjé  4 , Joseph Rutledge  5 , David Dickerson  6   7 , Timothy R Lubenow  8
Affiliations
Review

A Review of the Prospera Spinal Cord Stimulation System with Multiphase Stimulation and Proactive Care

Ramana K Naidu et al. Curr Pain Headache Rep. .

Abstract

Purpose of review: The purpose of this review is to describe the development and key features of the Prospera™ Spinal Cord Stimulation (SCS) System, as well as the clinical evidence supporting its use. Prospera delivers therapy using a proprietary multiphase stimulation paradigm and is the first SCS system to offer proactive care through automatic, objective, daily, remote device monitoring and remote programming capabilities.

Recent findings: Results from the recently published BENEFIT-02 trial support the short-term safety and efficacy of multiphase stimulation in patients with chronic pain. BENEFIT-03 is an ongoing, multicenter, single-arm study with 24-month follow-up; interim analyses suggest that multiphase therapy is safe and effective and that patients and clinicians have positive experiences with remote device management. Preliminary evidence suggests that the Prospera SCS System represents an opportunity to improve patient care by combining an effective multiphase stimulation paradigm with an efficient proactive care model.

Keywords: Chronic pain; Multiphase stimulation; Proactive care; Remote monitoring; Remote programming; Spinal cord stimulation.

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Conflict of interest statement

Compliance with Ethical Standards. Conflict of Interest: R.K. Naidu has served on Speakers Bureau for Abbott, Avanos, Boston Scientific, and Nalu; as a consultant for Abbott, Biotronik, Bioventus, Boston Scientific, Medtronic, Nalu, SPR Therapeutics, and Avanos; on an advisory/medical board for Abbott, Boston Scientific, Nalu, and SPR Therapeutics; and as an investigator for Abbott and Boston Scientific. L. Kapural has consulted for Nevro, Abbott, Medtronic, Nalu, Saluda, and Biotronik and participated in research for Nevro, Medtronic, Gimer Medical, Neuros, Saluda, Biotronik, and SPR Therapeutics. S. Li has consulted for Nevro (research grant), Boston Scientific (research grant), Saluda (research grant), Abbott, Avanos (research grant), Vertos, Nalu (research grant, shareholder), PainTeq (research grant), Averitas Pharma (research grant), SPR Therapeutics (research grant), and Biotronik (research grant); has received a research grant from SGX Medical; and has served on advisory boards for Saluda and Vertos. C. Tourjé has consulted for Nevro and Biotronik and participates in research for Biotronik and CornerLoc/TransLoc. J. Rutledge has received speaking and consulting fees from SPR Therapeutics, Boston Scientific, Abbott, TerSera, Vertos, and Biotronik. D. Dickerson has received speaking and consulting fees from SPR Therapeutics (research grant), Pfizer, Myovant, Abbott (research grant), Vertos, Nalu, Vertex and Biotronik. T.R. Lubenow has consulting agreements with Abbott, Boston Scientific, Biotronik, Pen Tec, and Pain Teq; and research grants with Abbott and Boston Scientific. Human and Animal Rights and Informed Consent: This review article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Graphic representation of RESONANCE multiphase stimulation (BIOTRONIK SE & Co. KG, Berlin, Germany) versus single-phase stimulation and proactive care enabled by remote device monitoring and remote programming. Inset image: © 2023, courtesy of BIOTRONIK. OOR, out of range; SCS, spinal cord stimulation
See this image and copyright information in PMC

References

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