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. 2025 Apr 1;64(14):e202422899.
doi: 10.1002/anie.202422899. Epub 2025 Jan 23.

Saturated F2-Rings from Alkenes

Yin Li  1 , Xiao-Bin Liu  1 , Vadym Sham  2   3 , Ivan Logvinenko  2   4 , Jiang-Hao Xue  1 , Jun-Yunzi Wu  1 , Jia-Luo Fu  1 , Shuang Lin  1 , Yuan Liu  1 , Qingjiang Li  1 , Pavel K Mykhailiuk  2   5 , Honggen Wang  1
Affiliations

Saturated F2-Rings from Alkenes

Yin Li et al. Angew Chem Int Ed Engl. .

Abstract

A general method to convert simple exocyclic alkenes into saturated F2-rings has been developed. The reaction involves reagent C6F5I(OAc)2. The reaction efficiently works on the mg-, g-, and even multigram scale.

Keywords: alkene; drug modification; fluorine; natural product; ring-expansion.

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