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. 2026 Jan;38(1-2):99-109.
doi: 10.1177/08982643251314064. Epub 2025 Jan 14.

Longitudinal Trends in Physical Activity Among Older Adults With and Without HIV in Uganda

Aneeka Ratnayake  1 , Yao Tong  2 , Zahra Reynolds  2 , Steffany Chamut  3   4 , Lien T Quach  2   5 , Phoebe Mbabazi  6 , Shruti Sagar  2 , Samuel Maling  7 , Crystal M North  2   8   9 , Eliza Passell  2 , Moka Yoo-Jeong  10 , Alexander C Tsai  9   11   12 , Robert Paul  13 , Christine S Ritchie  9   14   15 , Janet Seeley  16 , Susanne S Hoeppner  2   9 , Flavia Atwiine  12 , Edna Tindimwebwa  17 , Samson Okello  12   18 , Noeline Nakasujja  7 , Deanna Saylor  19 , Meredith L Greene  20   21 , Stephen Asiimwe  11   12   17 , Jeremy A Tanner  22 , Mark J Siedner  2   9   12 , Brianne Olivieri-Mui  1   23   24
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Free PMC article

Longitudinal Trends in Physical Activity Among Older Adults With and Without HIV in Uganda

Aneeka Ratnayake et al. J Aging Health. 2026 Jan.
Free PMC article

Abstract

IntroductionPhysical Activity (PA) and its links to frailty, quality of life (QoL), and other comorbidities in older Ugandans living with HIV remain under-explored.MethodsWe analyzed data from three annual assessments of older people living with HIV (PLWH) and age- and sex-similar people not living with HIV (PnLWH). We fitted linear generalized estimating equations (GEE) regression models to estimate the correlates of PA, including demographics, frailty, QoL, HIV, and other comorbidities.ResultsWe enrolled 297 PLWH and 302 PnLWH. Older age (b = -157.34, 95% CI [-222.84, -91.83]), living with HIV (b = -979.88 [95% CI: -1878.48, -81.28]), frailty (b = -3011.14 [95% CI: -4665.84, -1356.45]), and comorbidities (b = -2501.75 [95% CI: -3357.44, -1646.07]) were associated with lower overall PA. Higher general QoL (b = 89.96 [95% CI: 40.99, 138.94]) was associated with higher PA.ConclusionPA interventions may support wellbeing of older people in the region, and tailored interventions should be explored.

Keywords: HIV; Uganda; frailty; older adults; physical activity; quality of life.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: ACT reports receiving a financial honorarium from Elsevier, Inc for his work as Co-Editor in Chief of the Elsevier-owned journal SSM-Mental Health. MLG reports past grant funding from Gilead Sciences, Inc, which ended in December 2022. The other authors declare no conflicts of interest.