Regulatory B cells in parasitic infections: roles and therapeutic potential
- PMID: 39809978
- PMCID: PMC11732949
- DOI: 10.1007/s00436-024-08450-4
Regulatory B cells in parasitic infections: roles and therapeutic potential
Abstract
Parasitic infection is a complex process involving interactions among various immune cells. Regulatory B cells (Breg cells), a subset of B lymphocytes with immunosuppressive functions, play a role in modulating immune responses during infection to prevent excessive immune activation. This article reviews the origin, phenotype, and immunoregulatory mechanisms of Breg cells. We summarize the immunomodulatory roles of Breg cells in various parasitic infections. We also discuss the potential applications of activating Breg cells through parasitic infections and their derived molecules in the treatment of certain allergic, autoimmune, and inflammatory diseases. The aim is to provide new perspectives for the future treatment of parasitic diseases and other related conditions.
Keywords: Allergy; Immunoregulation; Inflammation; Parasitic infections; Regulatory B cells.
© 2025. The Author(s).
Conflict of interest statement
Declarations. Ethics approval: Clinical trial number: not applicable. Competing interests: The authors declare no competing interests.
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References
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- Arai H (2012) Biology of the Tapeworm Hymenolepis diminuta. Elsevier
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